Assay Detail
Binding
CHEMBL2345044
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Inhibition of human Cyp11B1 transfected in chinese hamster V79MZ cells using deoxycorticosterone as substrate incubated for 60 mins prior to substrate addition measured after 25 mins by HPLC analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | V79MZ |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aldosterone synthase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.56 | 6.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2331704 | — | — | 1 | 6.97 |
| CHEMBL2331706 | — | — | 1 | 6.39 |
| CHEMBL2331703 | — | — | 1 | 5.16 |
| CHEMBL2331700 | — | — | 1 | 4.76 |
| CHEMBL2331699 | — | — | 1 | 4.53 |
| CHEMBL2331702 | — | — | 1 | - |
| CHEMBL2331701 | — | — | 1 | - |
| CHEMBL2331705 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2331704 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL2331706 | — | IC50 | = | 407.0 | nM | 6.39 |
| CHEMBL2331703 | — | IC50 | = | 6930.0 | nM | 5.16 |
| CHEMBL2331700 | — | IC50 | = | 17296.0 | nM | 4.76 |
| CHEMBL2331699 | — | IC50 | = | 29540.0 | nM | 4.53 |
| CHEMBL2331702 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2331701 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2331705 | — | IC50 | > | 30000.0 | nM | - |