Assay Detail
Binding
CHEMBL2345121
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE11 (unknown origin) using FAM-cGMP and FAM-cAMP as substrate after 60 mins by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (CHEMBL2717) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis of quinoline derivatives: discovery of a potent and selective phosphodiesterase 5 inhibitor for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.61 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | 4.0 | 1 | 8.00 |
| CHEMBL1520 | VARDENAFIL | 4.0 | 1 | 6.62 |
| CHEMBL192 | SILDENAFIL | 4.0 | 1 | 5.21 |
| CHEMBL2333220 | — | — | 1 | - |
| CHEMBL2333219 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL779 | TADALAFIL | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL1520 | VARDENAFIL | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL192 | SILDENAFIL | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL2333220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2333219 | — | IC50 | > | 10000.0 | nM | - |