Assay Detail
Functional
CHEMBL2346229
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antitrypanosomal activity against Trypanosoma brucei rhodesiense after 48 hrs by CellTiter-Glo assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Trypanosoma brucei rhodesiense |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Trypanosoma brucei rhodesiense (CHEMBL612348) ↗| Type | ORGANISM |
| Organism | Trypanosoma brucei rhodesiense |
Publication
Novel naphthoquinone derivatives: synthesis and activity against human African trypanosomiasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.59 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2335793 | — | — | 1 | 7.30 |
| CHEMBL2335792 | — | — | 1 | 7.16 |
| CHEMBL2335791 | — | — | 1 | 7.05 |
| CHEMBL2335790 | — | — | 1 | 6.82 |
| CHEMBL155563 | — | — | 1 | 6.77 |
| CHEMBL2335789 | — | — | 1 | 6.35 |
| CHEMBL2335799 | — | — | 1 | 6.17 |
| CHEMBL2335798 | — | — | 1 | 6.10 |
| CHEMBL2335795 | — | — | 1 | 6.10 |
| CHEMBL2335797 | — | — | 1 | 5.70 |
| CHEMBL2335794 | — | — | 1 | 5.70 |
| CHEMBL2336198 | — | — | 1 | 5.52 |
| CHEMBL2336197 | — | — | 1 | 5.40 |
| CHEMBL2335796 | — | — | 1 | 5.40 |
| CHEMBL2336201 | — | — | 1 | 5.22 |
| CHEMBL2336196 | — | — | 1 | 5.16 |
| CHEMBL2336200 | — | — | 1 | 5.10 |
| CHEMBL2335787 | — | — | 1 | 5.00 |
| CHEMBL2335788 | — | — | 1 | 4.96 |
| CHEMBL2336199 | — | — | 1 | 4.92 |
| CHEMBL2336202 | — | — | 1 | 4.82 |
| CHEMBL2336195 | — | — | 1 | 4.75 |
| CHEMBL1631458 | — | — | 1 | 4.75 |
| CHEMBL1382429 | — | — | 1 | 4.70 |
| CHEMBL2335800 | — | — | 1 | 4.70 |
| CHEMBL2336194 | — | — | 1 | 4.68 |
| CHEMBL2336193 | — | — | 1 | 4.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2335793 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2335792 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2335791 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL2335790 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL155563 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL2335789 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL2335799 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL2335798 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2335795 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL2335797 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2335794 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL2336198 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2336197 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2335796 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2336201 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL2336196 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL2336200 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2335787 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2335788 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2336199 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2336202 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL2336195 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1631458 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1382429 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2335800 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2336194 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL2336193 | — | IC50 | = | 24000.0 | nM | 4.62 |