Assay Detail
ADMET
CHEMBL2350844
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Inhibition of CYP2D6 (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.95 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347409 | — | — | 1 | 5.52 |
| CHEMBL2347407 | — | — | 1 | 5.30 |
| CHEMBL2347420 | — | — | 1 | 4.96 |
| CHEMBL2347999 | — | — | 1 | 4.92 |
| CHEMBL2347406 | — | — | 1 | 4.92 |
| CHEMBL2347416 | — | — | 1 | 4.72 |
| CHEMBL2347419 | — | — | 1 | 4.32 |
| CHEMBL2348858 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347409 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL2347407 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2347420 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL2347999 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2347406 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2347416 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2347419 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL2348858 | — | IC50 | > | 8000.0 | nM | - |