Assay Detail
ADMET
CHEMBL2350845
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Inhibition of CYP2C9 (unknown origin)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.20 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2347418 | — | — | 1 | 5.40 |
| CHEMBL2347413 | — | — | 1 | 5.40 |
| CHEMBL2347417 | — | — | 1 | 5.30 |
| CHEMBL2347988 | — | — | 1 | 5.10 |
| CHEMBL2348850 | — | — | 1 | 4.80 |
| CHEMBL2347997 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2347418 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2347413 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2347417 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2347988 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL2348850 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL2347997 | — | IC50 | > | 8000.0 | nM | - |