Assay Detail
Binding
CHEMBL2352644
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Displacement of [3H]MK-801 from NMDA receptor complex (unknown origin) after 40 mins
45
Total Activities
45
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Improving the inhibitory activity of arylidenaminoguanidine compounds at the N-methyl-D-aspartate receptor complex from a recursive computational-experimental structure-activity relationship study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 45 | 4.54 | 5.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54151 | — | — | 1 | 5.44 |
| CHEMBL2346953 | — | — | 1 | 5.22 |
| CHEMBL2346945 | — | — | 1 | 5.15 |
| CHEMBL2346946 | — | — | 1 | 5.11 |
| CHEMBL105167 | — | — | 1 | 5.10 |
| CHEMBL2346939 | — | — | 1 | 5.07 |
| CHEMBL2346937 | — | — | 1 | 5.06 |
| CHEMBL2346943 | — | — | 1 | 4.99 |
| CHEMBL2346935 | — | — | 1 | 4.94 |
| CHEMBL105099 | — | — | 1 | 4.77 |
| CHEMBL2346944 | — | — | 1 | 4.74 |
| CHEMBL2346955 | — | — | 1 | 4.64 |
| CHEMBL2346952 | — | — | 1 | 4.60 |
| CHEMBL2346936 | — | — | 1 | 4.58 |
| CHEMBL2346938 | — | — | 1 | 4.57 |
| CHEMBL105703 | — | — | 1 | 4.54 |
| CHEMBL534939 | — | — | 1 | 4.49 |
| CHEMBL2346814 | — | — | 1 | 4.48 |
| CHEMBL2346950 | — | — | 1 | 4.42 |
| CHEMBL53180 | — | — | 1 | 4.41 |
| CHEMBL2346954 | — | — | 1 | 4.37 |
| CHEMBL2346956 | — | — | 1 | 4.36 |
| CHEMBL2346815 | — | — | 1 | 4.31 |
| CHEMBL2346816 | — | — | 1 | 4.30 |
| CHEMBL2346940 | — | — | 1 | 4.26 |
| CHEMBL2346817 | — | — | 1 | 4.24 |
| CHEMBL2346812 | — | — | 1 | 4.23 |
| CHEMBL2346947 | — | — | 1 | 4.20 |
| CHEMBL2346959 | — | — | 1 | 4.15 |
| CHEMBL296174 | — | — | 1 | 4.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54151 | — | IC50 | = | 3630.78 | nM | 5.44 |
| CHEMBL2346953 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL2346945 | — | IC50 | = | 7079.46 | nM | 5.15 |
| CHEMBL2346946 | — | IC50 | = | 7762.47 | nM | 5.11 |
| CHEMBL105167 | — | IC50 | = | 7943.28 | nM | 5.10 |
| CHEMBL2346939 | — | IC50 | = | 8511.38 | nM | 5.07 |
| CHEMBL2346937 | — | IC50 | = | 8709.64 | nM | 5.06 |
| CHEMBL2346943 | — | IC50 | = | 10232.93 | nM | 4.99 |
| CHEMBL2346935 | — | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL105099 | — | IC50 | = | 16982.44 | nM | 4.77 |
| CHEMBL2346944 | — | IC50 | = | 18197.01 | nM | 4.74 |
| CHEMBL2346955 | — | IC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL2346952 | — | IC50 | = | 25118.86 | nM | 4.60 |
| CHEMBL2346936 | — | IC50 | = | 26302.68 | nM | 4.58 |
| CHEMBL2346938 | — | IC50 | = | 26915.35 | nM | 4.57 |
| CHEMBL105703 | — | IC50 | = | 28840.32 | nM | 4.54 |
| CHEMBL534939 | — | IC50 | = | 32359.37 | nM | 4.49 |
| CHEMBL2346814 | — | IC50 | = | 33113.11 | nM | 4.48 |
| CHEMBL2346950 | — | IC50 | = | 38018.94 | nM | 4.42 |
| CHEMBL53180 | — | IC50 | = | 38904.51 | nM | 4.41 |
| CHEMBL2346954 | — | IC50 | = | 42657.95 | nM | 4.37 |
| CHEMBL2346956 | — | IC50 | = | 43651.58 | nM | 4.36 |
| CHEMBL2346815 | — | IC50 | = | 48977.88 | nM | 4.31 |
| CHEMBL2346816 | — | IC50 | = | 50118.72 | nM | 4.30 |
| CHEMBL2346940 | — | IC50 | = | 54954.09 | nM | 4.26 |
| CHEMBL2346817 | — | IC50 | = | 57543.99 | nM | 4.24 |
| CHEMBL2346812 | — | IC50 | = | 58884.37 | nM | 4.23 |
| CHEMBL2346947 | — | IC50 | = | 63095.73 | nM | 4.20 |
| CHEMBL2346959 | — | IC50 | = | 70794.58 | nM | 4.15 |
| CHEMBL296174 | — | IC50 | = | 72443.6 | nM | 4.14 |
| CHEMBL2346958 | — | IC50 | = | 72443.6 | nM | 4.14 |
| CHEMBL2346942 | — | IC50 | = | 74131.02 | nM | 4.13 |
| CHEMBL104315 | — | IC50 | = | 77624.71 | nM | 4.11 |
| CHEMBL320890 | — | IC50 | = | 81283.05 | nM | 4.09 |
| CHEMBL2346941 | — | IC50 | = | 91201.08 | nM | 4.04 |
| CHEMBL2346933 | — | IC50 | = | 95499.26 | nM | 4.02 |
| CHEMBL2346949 | — | IC50 | = | 223872.11 | nM | - |
| CHEMBL2346951 | — | IC50 | = | 213796.21 | nM | - |
| CHEMBL2346934 | — | IC50 | = | 109647.82 | nM | - |
| CHEMBL2346948 | — | IC50 | = | 109647.82 | nM | - |
| CHEMBL2346957 | — | IC50 | = | 229086.77 | nM | - |
| CHEMBL2346932 | — | IC50 | = | 676082.98 | nM | - |
| CHEMBL2346931 | — | IC50 | = | 537031.8 | nM | - |
| CHEMBL2346813 | — | IC50 | = | 181970.09 | nM | - |
| CHEMBL106177 | — | IC50 | = | 154881.66 | nM | - |