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Assay Detail

CHEMBL2354227

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PubChem BioAssay. Fluorescence-based cell-based primary high throughput dose response assay to identify antagonists of the Galanin Receptor 3 (GalR3). (Class of assay: confirmatory)
ChEMBL ↗
236
Total Activities
235
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Galanin receptor type 3 (CHEMBL2731) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 236 5.92 8.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL225963 PYRIDABEN — 1 8.18
CHEMBL267630 — — 1 7.81
CHEMBL1873644 — — 1 7.77
CHEMBL1721226 — — 1 7.41
CHEMBL1423004 — — 1 7.06
CHEMBL1878609 — — 1 6.90
CHEMBL1323872 — — 1 6.89
CHEMBL1550278 — — 1 6.89
CHEMBL1386344 — — 1 6.85
CHEMBL1725453 — — 1 6.85
CHEMBL1461631 — — 1 6.84
CHEMBL1319304 — — 1 6.83
CHEMBL1499354 — — 1 6.81
CHEMBL1340112 — — 1 6.80
CHEMBL1705098 — — 1 6.80
CHEMBL152649 CHLORMIDAZOLE 2.0 1 6.69
CHEMBL1492752 — — 1 6.62
CHEMBL1422429 — — 1 6.61
CHEMBL1546066 — — 1 6.58
CHEMBL95431 CARBOXYAMIDOTRIAZOLE 3.0 1 6.52
CHEMBL1425552 — — 1 6.49
CHEMBL1604200 — — 1 6.48
CHEMBL1903414 — — 1 6.46
CHEMBL1981589 — — 1 6.45
CHEMBL1711360 — — 1 6.44
CHEMBL1569489 — — 1 6.43
CHEMBL1423660 — — 1 6.43
CHEMBL1400272 — — 1 6.42
CHEMBL1428566 — — 1 6.42
CHEMBL2136916 — — 1 6.41

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL225963 PYRIDABEN IC50 = 6.57 nM 8.18
CHEMBL267630 — IC50 = 15.41 nM 7.81
CHEMBL1873644 — IC50 = 17.14 nM 7.77
CHEMBL1721226 — IC50 = 38.65 nM 7.41
CHEMBL1423004 — IC50 = 86.87 nM 7.06
CHEMBL1878609 — IC50 = 126.34 nM 6.90
CHEMBL1323872 — IC50 = 128.28 nM 6.89
CHEMBL1550278 — IC50 = 128.42 nM 6.89
CHEMBL1725453 — IC50 = 140.16 nM 6.85
CHEMBL1386344 — IC50 = 142.05 nM 6.85
CHEMBL1461631 — IC50 = 143.0 nM 6.84
CHEMBL1319304 — IC50 = 147.93 nM 6.83
CHEMBL1499354 — IC50 = 154.72 nM 6.81
CHEMBL1340112 — IC50 = 157.61 nM 6.80
CHEMBL1705098 — IC50 = 158.36 nM 6.80
CHEMBL152649 CHLORMIDAZOLE IC50 = 203.24 nM 6.69
CHEMBL1492752 — IC50 = 240.04 nM 6.62
CHEMBL1422429 — IC50 = 246.39 nM 6.61
CHEMBL1546066 — IC50 = 260.46 nM 6.58
CHEMBL95431 CARBOXYAMIDOTRIAZOLE IC50 = 303.14 nM 6.52
CHEMBL1425552 — IC50 = 322.09 nM 6.49
CHEMBL1604200 — IC50 = 330.65 nM 6.48
CHEMBL1903414 — IC50 = 348.52 nM 6.46
CHEMBL1981589 — IC50 = 358.39 nM 6.45
CHEMBL1711360 — IC50 = 362.58 nM 6.44
CHEMBL1423660 — IC50 = 371.44 nM 6.43
CHEMBL1569489 — IC50 = 367.22 nM 6.43
CHEMBL1400272 — IC50 = 378.74 nM 6.42
CHEMBL1428566 — IC50 = 382.84 nM 6.42
CHEMBL2136916 — IC50 = 391.72 nM 6.41
CHEMBL2355112 — IC50 = 400.33 nM 6.40
CHEMBL1300327 — IC50 = 399.9 nM 6.40
CHEMBL1424583 — IC50 = 399.11 nM 6.40
CHEMBL1610300 — IC50 = 407.86 nM 6.39
CHEMBL1462215 — IC50 = 403.97 nM 6.39
CHEMBL1437030 — IC50 = 419.43 nM 6.38
CHEMBL1603001 — IC50 = 430.23 nM 6.37
CHEMBL1493864 — IC50 = 449.14 nM 6.35
CHEMBL1405288 — IC50 = 447.54 nM 6.35
CHEMBL1413056 — IC50 = 482.08 nM 6.32
CHEMBL1884207 — IC50 = 502.85 nM 6.30
CHEMBL1446412 — IC50 = 512.94 nM 6.29
CHEMBL1494282 — IC50 = 546.97 nM 6.26
CHEMBL1490503 — IC50 = 580.9 nM 6.24
CHEMBL1736587 — IC50 = 617.81 nM 6.21
CHEMBL1717339 — IC50 = 626.1 nM 6.20
CHEMBL1376266 — IC50 = 762.09 nM 6.12
CHEMBL1380444 — IC50 = 804.68 nM 6.09
CHEMBL1412747 — IC50 = 874.17 nM 6.06
CHEMBL1487720 — IC50 = 873.62 nM 6.06