Compound Detail
CHEMBL1494282
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Basic Information
| ChEMBL ID | CHEMBL1494282 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AJZSDZUZDNNHMY-ZROIWOOFSA-N |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
389.8
MW (Da)
4.34
ALogP
6
HBA
1
HBD
93.8
PSA (Ų)
0.47
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 6.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Galanin receptor type 3 CHEMBL2731 | IC50 | 6.26 | 6.26 | 547.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.61 | 5.61 | 2452.0 | 1 |
| No relevant target CHEMBL2362975 | IC50 | 4.84 | 4.84 | 14495.0 | 1 |
| Mitochondrial import inner membrane translocase subunit TIM10 CHEMBL1741194 | IC50 | 4.65 | 4.65 | 22500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Galanin receptor type 3 | IC50 | = | 546.97 | nM | 6.26 | PubChem BioAssay. Fluorescence-based cell-based primary high throughput dose res... | - |
| Unchecked | IC50 | = | 2452.0 | nM | 5.61 | PubChem BioAssay. Fluorescence-based biochemical high throughput dose response a... | - |
| No relevant target | IC50 | = | 14495.0 | nM | 4.84 | PubChem BioAssay. Counterscreen for molecules that bind rCAG RNA repeats: fluore... | - |
| Mitochondrial import inner membrane translocase subunit TIM10 | IC50 | = | 22500.0 | nM | 4.65 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
Data from ChEMBL 36 via Core Engine