Assay Detail
Functional
CHEMBL2363172
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SANGER: Inhibition of human D-542MG cell growth in a cell viability assay.
94
Total Activities
93
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | D-542MG |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 5.39 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.48 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.16 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 8.12 |
| CHEMBL64925 | MG-132 | — | 1 | 7.22 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.11 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.08 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.86 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 6.79 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.77 |
| CHEMBL2363137 | — | — | 1 | 6.56 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.54 |
| CHEMBL585951 | — | — | 1 | 6.45 |
| CHEMBL217354 | — | — | 1 | 6.33 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.24 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.22 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.00 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.97 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.89 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.85 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.78 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 5.73 |
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 5.73 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.73 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 5.72 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.72 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 5.72 |
| CHEMBL1673039 | — | — | 1 | 5.70 |
| CHEMBL221137 | EMBELIN | — | 1 | 5.50 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.49 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.3288 | nM | 9.48 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 6.929 | nM | 8.16 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 7.559 | nM | 8.12 |
| CHEMBL64925 | MG-132 | IC50 | = | 59.57 | nM | 7.22 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 77.92 | nM | 7.11 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 83.31 | nM | 7.08 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 139.65 | nM | 6.86 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 162.78 | nM | 6.79 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 169.86 | nM | 6.77 |
| CHEMBL2363137 | — | IC50 | = | 277.27 | nM | 6.56 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 291.41 | nM | 6.54 |
| CHEMBL585951 | — | IC50 | = | 357.14 | nM | 6.45 |
| CHEMBL217354 | — | IC50 | = | 462.08 | nM | 6.33 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 580.88 | nM | 6.24 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 601.65 | nM | 6.22 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 1010.64 | nM | 6.00 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 1078.55 | nM | 5.97 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1279.94 | nM | 5.89 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1409.79 | nM | 5.85 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1653.05 | nM | 5.78 |
| CHEMBL473417 | VISMODEGIB | IC50 | = | 1867.37 | nM | 5.73 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 1850.77 | nM | 5.73 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1858.51 | nM | 5.73 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 1904.41 | nM | 5.72 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 1883.62 | nM | 5.72 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 1893.73 | nM | 5.72 |
| CHEMBL1673039 | — | IC50 | = | 2002.26 | nM | 5.70 |
| CHEMBL221137 | EMBELIN | IC50 | = | 3126.31 | nM | 5.50 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 3260.25 | nM | 5.49 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3442.22 | nM | 5.46 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 3876.68 | nM | 5.41 |
| CHEMBL1090090 | VX-702 | IC50 | = | 6392.72 | nM | 5.19 |
| CHEMBL573107 | — | IC50 | = | 6730.9 | nM | 5.17 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 7122.99 | nM | 5.15 |
| CHEMBL259181 | — | IC50 | = | 10277.58 | nM | 4.99 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 12315.17 | nM | 4.91 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 13430.62 | nM | 4.87 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 14922.23 | nM | 4.83 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 18021.85 | nM | 4.74 |
| CHEMBL188678 | — | IC50 | = | 21906.86 | nM | 4.66 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 22025.57 | nM | 4.66 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 22555.79 | nM | 4.65 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 23139.57 | nM | 4.64 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 23005.54 | nM | 4.64 |
| CHEMBL135561 | — | IC50 | = | 26024.96 | nM | 4.58 |
| CHEMBL472940 | — | IC50 | = | 27245.6 | nM | 4.57 |
| CHEMBL554 | LAPATINIB | IC50 | = | 29922.06 | nM | 4.52 |
| CHEMBL591429 | PAC-1 | IC50 | = | 29972.07 | nM | 4.52 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 32433.73 | nM | 4.49 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 32296.76 | nM | 4.49 |