Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2363210

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
SANGER: Inhibition of human ES1 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type ES1
Confidence 1 — Organism
Curated By Autocuration

Target

ES1 (CHEMBL2366146) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.96 10.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 10.57
CHEMBL96926 THAPSIGARGIN — 1 10.44
CHEMBL65 CAMPTOTHECIN -1.0 1 10.02
CHEMBL94657 PATUPILONE 3.0 1 9.65
CHEMBL325041 BORTEZOMIB 3.0 1 9.37
CHEMBL1972860 ELESCLOMOL 3.0 1 9.12
CHEMBL3545252 DOCETAXEL 4.0 1 9.11
CHEMBL252164 LUMINESPIB 2.0 1 8.57
CHEMBL553025 VINORELBINE 4.0 1 8.42
CHEMBL159 VINBLASTINE 4.0 1 8.33
CHEMBL105 MITOMYCIN 4.0 1 8.14
CHEMBL428647 PACLITAXEL 4.0 1 7.89
CHEMBL803 CYTARABINE 4.0 1 7.89
CHEMBL53463 DOXORUBICIN 4.0 1 7.86
CHEMBL575448 BMS-754807 2.0 1 7.80
CHEMBL34259 METHOTREXATE 4.0 1 7.79
CHEMBL1201182 TEMSIROLIMUS 4.0 1 7.61
CHEMBL514499 GW843682X — 1 7.60
CHEMBL6067492 BLEOMYCIN 4.0 1 7.57
CHEMBL1879463 DACTOLISIB 3.0 1 7.54
CHEMBL1256459 TORIN1 — 1 7.51
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.31
CHEMBL2041933 AZD-7762 1.0 1 7.15
CHEMBL603469 LESTAURTINIB 3.0 1 7.02
CHEMBL1091644 LINSITINIB 3.0 1 6.97
CHEMBL27759 ENTINOSTAT 3.0 1 6.95
CHEMBL36 PYRIMETHAMINE 4.0 1 6.91
CHEMBL217354 — — 1 6.89
CHEMBL44657 ETOPOSIDE 4.0 1 6.59
CHEMBL189963 PALBOCICLIB 4.0 1 6.59

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.02682 nM 10.57
CHEMBL96926 THAPSIGARGIN IC50 = 0.03648 nM 10.44
CHEMBL65 CAMPTOTHECIN IC50 = 0.09574 nM 10.02
CHEMBL94657 PATUPILONE IC50 = 0.2215 nM 9.65
CHEMBL325041 BORTEZOMIB IC50 = 0.4297 nM 9.37
CHEMBL1972860 ELESCLOMOL IC50 = 0.7491 nM 9.12
CHEMBL3545252 DOCETAXEL IC50 = 0.7701 nM 9.11
CHEMBL252164 LUMINESPIB IC50 = 2.665 nM 8.57
CHEMBL553025 VINORELBINE IC50 = 3.778 nM 8.42
CHEMBL159 VINBLASTINE IC50 = 4.714 nM 8.33
CHEMBL105 MITOMYCIN IC50 = 7.288 nM 8.14
CHEMBL428647 PACLITAXEL IC50 = 12.88 nM 7.89
CHEMBL803 CYTARABINE IC50 = 12.97 nM 7.89
CHEMBL53463 DOXORUBICIN IC50 = 13.72 nM 7.86
CHEMBL575448 BMS-754807 IC50 = 15.94 nM 7.80
CHEMBL34259 METHOTREXATE IC50 = 16.39 nM 7.79
CHEMBL1201182 TEMSIROLIMUS IC50 = 24.54 nM 7.61
CHEMBL514499 GW843682X IC50 = 25.0 nM 7.60
CHEMBL6067492 BLEOMYCIN IC50 = 26.7 nM 7.57
CHEMBL1879463 DACTOLISIB IC50 = 28.84 nM 7.54
CHEMBL1256459 TORIN1 IC50 = 30.97 nM 7.51
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 48.85 nM 7.31
CHEMBL2041933 AZD-7762 IC50 = 71.46 nM 7.15
CHEMBL603469 LESTAURTINIB IC50 = 95.29 nM 7.02
CHEMBL1091644 LINSITINIB IC50 = 106.96 nM 6.97
CHEMBL27759 ENTINOSTAT IC50 = 112.55 nM 6.95
CHEMBL36 PYRIMETHAMINE IC50 = 122.9 nM 6.91
CHEMBL217354 — IC50 = 129.56 nM 6.89
CHEMBL189963 PALBOCICLIB IC50 = 256.25 nM 6.59
CHEMBL44657 ETOPOSIDE IC50 = 254.34 nM 6.59
CHEMBL449158 BRYOSTATIN 1 IC50 = 262.73 nM 6.58
CHEMBL9470 SHIKONIN IC50 = 502.89 nM 6.30
CHEMBL1801204 AZD-8055 IC50 = 555.18 nM 6.26
CHEMBL288441 BOSUTINIB IC50 = 674.98 nM 6.17
CHEMBL585951 — IC50 = 685.25 nM 6.16
CHEMBL98 VORINOSTAT IC50 = 724.4 nM 6.14
CHEMBL379300 A-443654 IC50 = 739.09 nM 6.13
CHEMBL11359 CISPLATIN IC50 = 1024.01 nM 5.99
CHEMBL64925 MG-132 IC50 = 1079.21 nM 5.97
CHEMBL521686 OLAPARIB IC50 = 1114.08 nM 5.95
CHEMBL1079175 MK-2206 IC50 = 1240.65 nM 5.91
CHEMBL259181 — IC50 = 1381.24 nM 5.86
CHEMBL401930 — IC50 = 1615.27 nM 5.79
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 1638.44 nM 5.79
CHEMBL577784 BX-795 IC50 = 1754.51 nM 5.76
CHEMBL1173055 RUCAPARIB IC50 = 1727.76 nM 5.76
CHEMBL202721 — IC50 = 1768.34 nM 5.75
CHEMBL289228 TIPIFARNIB IC50 = 1962.99 nM 5.71
CHEMBL379975 — IC50 = 2122.02 nM 5.67
CHEMBL521851 PICTILISIB IC50 = 2213.26 nM 5.66