Assay Detail
Functional
CHEMBL2363227
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SANGER: Inhibition of human EW-24 cell growth in a cell viability assay.
105
Total Activities
104
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | EW-24 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 105 | 5.58 | 8.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.68 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.42 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.39 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.36 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.74 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.19 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.16 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.83 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.58 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.56 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.54 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.53 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.47 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.30 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 6.23 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 6.20 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.11 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.11 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.10 |
| CHEMBL379300 | A-443654 | — | 1 | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.07 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.04 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.01 |
| CHEMBL514499 | GW843682X | — | 1 | 5.92 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.83 |
| CHEMBL1256459 | TORIN1 | — | 1 | 5.81 |
| CHEMBL2144069 | — | — | 1 | 5.57 |
| CHEMBL300389 | — | — | 1 | 5.55 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 2.075 | nM | 8.68 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 3.835 | nM | 8.42 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.033 | nM | 8.39 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.332 | nM | 8.36 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 18.01 | nM | 7.74 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 64.83 | nM | 7.19 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 68.73 | nM | 7.16 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 149.46 | nM | 6.83 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 265.9 | nM | 6.58 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 274.74 | nM | 6.56 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 288.1 | nM | 6.54 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 289.1 | nM | 6.54 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 292.31 | nM | 6.53 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 339.84 | nM | 6.47 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 496.54 | nM | 6.30 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 594.43 | nM | 6.23 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 626.93 | nM | 6.20 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 782.97 | nM | 6.11 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 781.65 | nM | 6.11 |
| CHEMBL803 | CYTARABINE | IC50 | = | 793.93 | nM | 6.10 |
| CHEMBL379300 | A-443654 | IC50 | = | 837.09 | nM | 6.08 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 848.29 | nM | 6.07 |
| CHEMBL513909 | BI-2536 | IC50 | = | 920.02 | nM | 6.04 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 970.4 | nM | 6.01 |
| CHEMBL514499 | GW843682X | IC50 | = | 1193.84 | nM | 5.92 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1465.31 | nM | 5.83 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 1546.19 | nM | 5.81 |
| CHEMBL2144069 | — | IC50 | = | 2711.95 | nM | 5.57 |
| CHEMBL300389 | — | IC50 | = | 2795.04 | nM | 5.55 |
| CHEMBL509032 | TAE-684 | IC50 | = | 3664.34 | nM | 5.44 |
| CHEMBL1643959 | — | IC50 | = | 4589.15 | nM | 5.34 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 5040.38 | nM | 5.30 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 6285.1 | nM | 5.20 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 8765.4 | nM | 5.06 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 10244.72 | nM | 4.99 |
| CHEMBL401930 | — | IC50 | = | 10402.84 | nM | 4.98 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 14592.71 | nM | 4.84 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 16166.11 | nM | 4.79 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 21296.04 | nM | 4.67 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 21394.5 | nM | 4.67 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 23448.89 | nM | 4.63 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 25961.98 | nM | 4.59 |
| CHEMBL197603 | — | IC50 | = | 26325.89 | nM | 4.58 |
| CHEMBL554 | LAPATINIB | IC50 | = | 29125.85 | nM | 4.54 |
| CHEMBL64925 | MG-132 | IC50 | = | 32347.35 | nM | 4.49 |
| CHEMBL939 | GEFITINIB | IC50 | = | 35633.46 | nM | 4.45 |
| CHEMBL64925 | MG-132 | IC50 | = | 41422.41 | nM | 4.38 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 46172.3 | nM | 4.34 |
| CHEMBL221137 | EMBELIN | IC50 | = | 49693.64 | nM | 4.30 |
| CHEMBL591429 | PAC-1 | IC50 | = | 49508.78 | nM | 4.30 |