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Assay Detail

CHEMBL2363242

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Functional
SANGER: Inhibition of human GI-1 cell growth in a cell viability assay.
ChEMBL ↗
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type GI-1
Confidence 1 — Organism
Curated By Autocuration

Target

GI-1 (CHEMBL2366272) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 139 5.75 9.28

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.28
CHEMBL96926 THAPSIGARGIN — 1 9.26
CHEMBL325041 BORTEZOMIB 3.0 1 9.12
CHEMBL94657 PATUPILONE 3.0 1 8.61
CHEMBL888 GEMCITABINE 4.0 1 8.56
CHEMBL65 CAMPTOTHECIN -1.0 1 8.47
CHEMBL553025 VINORELBINE 4.0 1 8.45
CHEMBL159 VINBLASTINE 4.0 1 8.36
CHEMBL220241 GSK-269962A — 1 8.28
CHEMBL514499 GW843682X — 1 8.14
CHEMBL1972860 ELESCLOMOL 3.0 1 8.08
CHEMBL428647 PACLITAXEL 4.0 1 7.86
CHEMBL513909 BI-2536 2.0 1 7.86
CHEMBL1256459 TORIN1 — 1 7.61
CHEMBL105 MITOMYCIN 4.0 1 7.45
CHEMBL1879463 DACTOLISIB 3.0 1 7.22
CHEMBL53463 DOXORUBICIN 4.0 1 7.16
CHEMBL413 SIROLIMUS 4.0 1 7.15
CHEMBL300389 — — 1 7.11
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.11
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.97
CHEMBL217354 — — 1 6.89
CHEMBL109480 TANESPIMYCIN 3.0 1 6.84
CHEMBL252164 LUMINESPIB 2.0 1 6.83
CHEMBL585951 — — 1 6.77
CHEMBL379300 A-443654 — 1 6.73
CHEMBL2041933 AZD-7762 1.0 1 6.71
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.56
CHEMBL608533 MIDOSTAURIN 4.0 1 6.50
CHEMBL803 CYTARABINE 4.0 1 6.47

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.5276 nM 9.28
CHEMBL96926 THAPSIGARGIN IC50 = 0.5493 nM 9.26
CHEMBL325041 BORTEZOMIB IC50 = 0.7644 nM 9.12
CHEMBL94657 PATUPILONE IC50 = 2.431 nM 8.61
CHEMBL888 GEMCITABINE IC50 = 2.764 nM 8.56
CHEMBL65 CAMPTOTHECIN IC50 = 3.365 nM 8.47
CHEMBL553025 VINORELBINE IC50 = 3.536 nM 8.45
CHEMBL159 VINBLASTINE IC50 = 4.362 nM 8.36
CHEMBL220241 GSK-269962A IC50 = 5.227 nM 8.28
CHEMBL514499 GW843682X IC50 = 7.303 nM 8.14
CHEMBL1972860 ELESCLOMOL IC50 = 8.261 nM 8.08
CHEMBL428647 PACLITAXEL IC50 = 13.73 nM 7.86
CHEMBL513909 BI-2536 IC50 = 13.83 nM 7.86
CHEMBL1256459 TORIN1 IC50 = 24.69 nM 7.61
CHEMBL105 MITOMYCIN IC50 = 35.16 nM 7.45
CHEMBL1879463 DACTOLISIB IC50 = 60.3 nM 7.22
CHEMBL53463 DOXORUBICIN IC50 = 69.65 nM 7.16
CHEMBL413 SIROLIMUS IC50 = 70.39 nM 7.15
CHEMBL300389 — IC50 = 78.15 nM 7.11
CHEMBL449158 BRYOSTATIN 1 IC50 = 78.57 nM 7.11
CHEMBL1201182 TEMSIROLIMUS IC50 = 106.88 nM 6.97
CHEMBL217354 — IC50 = 127.63 nM 6.89
CHEMBL109480 TANESPIMYCIN IC50 = 145.58 nM 6.84
CHEMBL252164 LUMINESPIB IC50 = 147.72 nM 6.83
CHEMBL585951 — IC50 = 171.07 nM 6.77
CHEMBL379300 A-443654 IC50 = 187.46 nM 6.73
CHEMBL2041933 AZD-7762 IC50 = 195.61 nM 6.71
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 274.87 nM 6.56
CHEMBL608533 MIDOSTAURIN IC50 = 319.02 nM 6.50
CHEMBL803 CYTARABINE IC50 = 338.83 nM 6.47
CHEMBL603469 LESTAURTINIB IC50 = 545.78 nM 6.26
CHEMBL9470 SHIKONIN IC50 = 568.29 nM 6.25
CHEMBL44657 ETOPOSIDE IC50 = 713.17 nM 6.15
CHEMBL575448 BMS-754807 IC50 = 725.02 nM 6.14
CHEMBL401930 — IC50 = 912.55 nM 6.04
CHEMBL509032 TAE-684 IC50 = 1097.98 nM 5.96
CHEMBL6067492 BLEOMYCIN IC50 = 1200.01 nM 5.92
CHEMBL2165191 AZD-6482 IC50 = 1318.08 nM 5.88
CHEMBL5416410 DASATINIB IC50 = 1362.2 nM 5.87
CHEMBL2363137 — IC50 = 1431.61 nM 5.84
CHEMBL64925 MG-132 IC50 = 1471.31 nM 5.83
CHEMBL11359 CISPLATIN IC50 = 2063.06 nM 5.68
CHEMBL217092 SARACATINIB IC50 = 2160.84 nM 5.67
CHEMBL477772 PAZOPANIB IC50 = 2229.51 nM 5.65
CHEMBL98 VORINOSTAT IC50 = 2305.43 nM 5.64
CHEMBL601719 CRIZOTINIB IC50 = 2496.59 nM 5.60
CHEMBL515416 — IC50 = 2702.88 nM 5.57
CHEMBL1242367 — IC50 = 2945.3 nM 5.53
CHEMBL27759 ENTINOSTAT IC50 = 2929.57 nM 5.53
CHEMBL507361 MIRDAMETINIB IC50 = 3011.45 nM 5.52