Assay Detail
Functional
CHEMBL2363300
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human Hs-578-T cell growth in a cell viability assay.
98
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Hs-578-T |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 98 | 5.53 | 8.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.57 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.89 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.81 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.76 |
| CHEMBL217354 | — | — | 1 | 7.63 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.61 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.18 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.14 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.94 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.84 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.74 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.34 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.24 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.22 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.16 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.08 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.00 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.92 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.90 |
| CHEMBL3349342 | — | — | 1 | 5.75 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.70 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.67 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.64 |
| CHEMBL393929 | — | — | 1 | 5.64 |
| CHEMBL577784 | BX-795 | — | 1 | 5.62 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.61 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 5.46 |
| CHEMBL189584 | PD-173074 | — | 1 | 5.43 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.39 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.716 | nM | 8.57 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 12.79 | nM | 7.89 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 15.54 | nM | 7.81 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 17.31 | nM | 7.76 |
| CHEMBL217354 | — | IC50 | = | 23.59 | nM | 7.63 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 24.58 | nM | 7.61 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 65.9 | nM | 7.18 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 72.08 | nM | 7.14 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 115.35 | nM | 6.94 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 144.69 | nM | 6.84 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 182.92 | nM | 6.74 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 452.78 | nM | 6.34 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 570.63 | nM | 6.24 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 598.51 | nM | 6.22 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 686.48 | nM | 6.16 |
| CHEMBL803 | CYTARABINE | IC50 | = | 838.86 | nM | 6.08 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 996.64 | nM | 6.00 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1195.65 | nM | 5.92 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1258.17 | nM | 5.90 |
| CHEMBL3349342 | — | IC50 | = | 1758.92 | nM | 5.75 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 2017.82 | nM | 5.70 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 2114.33 | nM | 5.67 |
| CHEMBL393929 | — | IC50 | = | 2277.99 | nM | 5.64 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2307.09 | nM | 5.64 |
| CHEMBL577784 | BX-795 | IC50 | = | 2415.87 | nM | 5.62 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 2455.25 | nM | 5.61 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 3495.04 | nM | 5.46 |
| CHEMBL189584 | PD-173074 | IC50 | = | 3678.73 | nM | 5.43 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 4083.06 | nM | 5.39 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 4314.68 | nM | 5.37 |
| CHEMBL202721 | — | IC50 | = | 4549.19 | nM | 5.34 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 4776.55 | nM | 5.32 |
| CHEMBL105442 | CI-1040 | IC50 | = | 5537.94 | nM | 5.26 |
| CHEMBL573107 | — | IC50 | = | 5836.07 | nM | 5.23 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 6223.4 | nM | 5.21 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 6203.02 | nM | 5.21 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 10845.8 | nM | 4.96 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 11300.03 | nM | 4.95 |
| CHEMBL221137 | EMBELIN | IC50 | = | 11144.74 | nM | 4.95 |
| CHEMBL2363137 | — | IC50 | = | 11523.41 | nM | 4.94 |
| CHEMBL222102 | KU-55933 | IC50 | = | 15418.19 | nM | 4.81 |
| CHEMBL191384 | — | IC50 | = | 16319.55 | nM | 4.79 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 17658.41 | nM | 4.75 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 17814.88 | nM | 4.75 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 18575.86 | nM | 4.73 |
| CHEMBL188678 | — | IC50 | = | 20558.26 | nM | 4.69 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 22066.91 | nM | 4.66 |
| CHEMBL585951 | — | IC50 | = | 23132.95 | nM | 4.64 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 24709.73 | nM | 4.61 |
| CHEMBL939 | GEFITINIB | IC50 | = | 27529.94 | nM | 4.56 |