Assay Detail
Functional
CHEMBL2363382
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SANGER: Inhibition of human LN-405 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LN-405 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.21 | 8.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.32 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.91 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.20 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.06 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.99 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.87 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.87 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.61 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.38 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.29 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.13 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.07 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.06 |
| CHEMBL585951 | — | — | 1 | 6.00 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.89 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.86 |
| CHEMBL217354 | — | — | 1 | 5.80 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.74 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.67 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 5.61 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.50 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.50 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.47 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.38 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.24 |
| CHEMBL1173055 | RUCAPARIB | 4.0 | 1 | 5.19 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.17 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.16 |
| CHEMBL399530 | — | — | 1 | 5.07 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.819 | nM | 8.32 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 12.4 | nM | 7.91 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 63.85 | nM | 7.20 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 87.79 | nM | 7.06 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 103.27 | nM | 6.99 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 134.64 | nM | 6.87 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 136.23 | nM | 6.87 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 245.04 | nM | 6.61 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 416.87 | nM | 6.38 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 517.64 | nM | 6.29 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 743.6 | nM | 6.13 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 859.06 | nM | 6.07 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 877.31 | nM | 6.06 |
| CHEMBL585951 | — | IC50 | = | 990.76 | nM | 6.00 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1280.21 | nM | 5.89 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1392.64 | nM | 5.86 |
| CHEMBL217354 | — | IC50 | = | 1583.77 | nM | 5.80 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1801.43 | nM | 5.74 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 2154.28 | nM | 5.67 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2444.62 | nM | 5.61 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 2895.53 | nM | 5.54 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 3188.26 | nM | 5.50 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3135.18 | nM | 5.50 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3363.25 | nM | 5.47 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 4157.28 | nM | 5.38 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 5730.85 | nM | 5.24 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 6418.72 | nM | 5.19 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 6796.72 | nM | 5.17 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 6914.68 | nM | 5.16 |
| CHEMBL399530 | — | IC50 | = | 8471.51 | nM | 5.07 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 11320.06 | nM | 4.95 |
| CHEMBL573107 | — | IC50 | = | 11592.69 | nM | 4.94 |
| CHEMBL2363137 | — | IC50 | = | 11866.85 | nM | 4.93 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 11844.79 | nM | 4.93 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 15458.21 | nM | 4.81 |
| CHEMBL803 | CYTARABINE | IC50 | = | 17148.56 | nM | 4.77 |
| CHEMBL221137 | EMBELIN | IC50 | = | 18842.24 | nM | 4.72 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 19907.59 | nM | 4.70 |
| CHEMBL2134202 | — | IC50 | = | 20896.46 | nM | 4.68 |
| CHEMBL191384 | — | IC50 | = | 22051.35 | nM | 4.66 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 22591.28 | nM | 4.65 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 23432.78 | nM | 4.63 |
| CHEMBL577784 | BX-795 | IC50 | = | 23920.65 | nM | 4.62 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 24847.77 | nM | 4.61 |
| CHEMBL255342 | — | IC50 | = | 29544.1 | nM | 4.53 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 31798.34 | nM | 4.50 |
| CHEMBL939 | GEFITINIB | IC50 | = | 35430.75 | nM | 4.45 |
| CHEMBL202721 | — | IC50 | = | 37845.12 | nM | 4.42 |
| CHEMBL3349342 | — | IC50 | = | 39507.99 | nM | 4.40 |
| CHEMBL258844 | — | IC50 | = | 45283.38 | nM | 4.34 |