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Assay Detail

CHEMBL2363386

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
SANGER: Inhibition of human LP-1 cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LP-1
Confidence 1 — Organism
Curated By Autocuration

Target

LP-1 (CHEMBL2366066) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 5.36 8.39

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96926 THAPSIGARGIN — 1 8.39
CHEMBL300389 — — 1 7.28
CHEMBL325041 BORTEZOMIB 3.0 1 7.21
CHEMBL514499 GW843682X — 1 7.20
CHEMBL1256459 TORIN1 — 1 7.05
CHEMBL513909 BI-2536 2.0 1 6.85
CHEMBL94657 PATUPILONE 3.0 1 6.70
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.67
CHEMBL428647 PACLITAXEL 4.0 1 6.55
CHEMBL553025 VINORELBINE 4.0 1 6.51
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.36
CHEMBL585951 — — 1 6.32
CHEMBL9470 SHIKONIN — 1 6.16
CHEMBL252164 LUMINESPIB 2.0 1 5.97
CHEMBL27759 ENTINOSTAT 3.0 1 5.89
CHEMBL509032 TAE-684 — 1 5.73
CHEMBL1091644 LINSITINIB 3.0 1 5.65
CHEMBL392695 S-TRITYL-L-CYSTEINE — 1 5.51
CHEMBL180127 SALUBRINAL — 1 5.47
CHEMBL512504 — — 1 5.42
CHEMBL1190711 — — 1 5.39
CHEMBL105 MITOMYCIN 4.0 1 5.34
CHEMBL64925 MG-132 — 2 5.33
CHEMBL413 SIROLIMUS 4.0 1 5.27
CHEMBL575448 BMS-754807 2.0 1 5.20
CHEMBL888 GEMCITABINE 4.0 1 5.14
CHEMBL5416410 DASATINIB 4.0 1 5.12
CHEMBL401930 — — 1 5.09
CHEMBL191384 — — 1 5.07
CHEMBL535 SUNITINIB 4.0 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96926 THAPSIGARGIN IC50 = 4.083 nM 8.39
CHEMBL300389 — IC50 = 52.09 nM 7.28
CHEMBL325041 BORTEZOMIB IC50 = 61.28 nM 7.21
CHEMBL514499 GW843682X IC50 = 62.53 nM 7.20
CHEMBL1256459 TORIN1 IC50 = 89.38 nM 7.05
CHEMBL513909 BI-2536 IC50 = 142.4 nM 6.85
CHEMBL94657 PATUPILONE IC50 = 200.47 nM 6.70
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 213.02 nM 6.67
CHEMBL428647 PACLITAXEL IC50 = 280.57 nM 6.55
CHEMBL553025 VINORELBINE IC50 = 311.32 nM 6.51
CHEMBL449158 BRYOSTATIN 1 IC50 = 441.92 nM 6.36
CHEMBL585951 — IC50 = 482.55 nM 6.32
CHEMBL9470 SHIKONIN IC50 = 686.37 nM 6.16
CHEMBL252164 LUMINESPIB IC50 = 1069.3 nM 5.97
CHEMBL27759 ENTINOSTAT IC50 = 1299.47 nM 5.89
CHEMBL509032 TAE-684 IC50 = 1871.43 nM 5.73
CHEMBL1091644 LINSITINIB IC50 = 2258.07 nM 5.65
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 3111.97 nM 5.51
CHEMBL180127 SALUBRINAL IC50 = 3371.12 nM 5.47
CHEMBL512504 — IC50 = 3790.42 nM 5.42
CHEMBL1190711 — IC50 = 4023.41 nM 5.39
CHEMBL105 MITOMYCIN IC50 = 4559.67 nM 5.34
CHEMBL64925 MG-132 IC50 = 4723.71 nM 5.33
CHEMBL413 SIROLIMUS IC50 = 5412.91 nM 5.27
CHEMBL575448 BMS-754807 IC50 = 6273.56 nM 5.20
CHEMBL888 GEMCITABINE IC50 = 7309.69 nM 5.14
CHEMBL5416410 DASATINIB IC50 = 7547.82 nM 5.12
CHEMBL401930 — IC50 = 8144.18 nM 5.09
CHEMBL191384 — IC50 = 8539.33 nM 5.07
CHEMBL535 SUNITINIB IC50 = 9780.83 nM 5.01
CHEMBL2363137 — IC50 = 10562.49 nM 4.98
CHEMBL1673039 — IC50 = 10860.79 nM 4.96
CHEMBL1242367 — IC50 = 12433.63 nM 4.91
CHEMBL2165191 AZD-6482 IC50 = 13352.76 nM 4.87
CHEMBL259181 — IC50 = 14167.94 nM 4.85
CHEMBL2144069 — IC50 = 14466.11 nM 4.84
CHEMBL258844 — IC50 = 16091.22 nM 4.79
CHEMBL608533 MIDOSTAURIN IC50 = 17506.16 nM 4.76
CHEMBL591429 PAC-1 IC50 = 19315.52 nM 4.71
CHEMBL572878 TOZASERTIB IC50 = 21343.22 nM 4.67
CHEMBL554 LAPATINIB IC50 = 23809.65 nM 4.62
CHEMBL601719 CRIZOTINIB IC50 = 25655.06 nM 4.59
CHEMBL64925 MG-132 IC50 = 29154.35 nM 4.54
CHEMBL472940 — IC50 = 30517.4 nM 4.51
CHEMBL14762 SELICICLIB IC50 = 33890.81 nM 4.47
CHEMBL1171837 PONATINIB IC50 = 34089.96 nM 4.47
CHEMBL1336 SORAFENIB IC50 = 33995.6 nM 4.47
CHEMBL379300 A-443654 IC50 = 34806.77 nM 4.46
CHEMBL553 ERLOTINIB IC50 = 39441.52 nM 4.40
CHEMBL197603 — IC50 = 48909.76 nM 4.31