Assay Detail
Functional
CHEMBL2363477
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SANGER: Inhibition of human NCI-H1581 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1581 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.50 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 9.26 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.66 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.37 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.91 |
| CHEMBL189584 | PD-173074 | — | 1 | 7.91 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.61 |
| CHEMBL514499 | GW843682X | — | 1 | 7.51 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.47 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.43 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.35 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.30 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.19 |
| CHEMBL217354 | — | — | 1 | 7.17 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.13 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.99 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.72 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.53 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.45 |
| CHEMBL300389 | — | — | 1 | 6.23 |
| CHEMBL379300 | A-443654 | — | 1 | 6.22 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.11 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.06 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.05 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.04 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.01 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.93 |
| CHEMBL585951 | — | — | 1 | 5.87 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 5.87 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.87 |
| CHEMBL1289926 | AXITINIB | 4.0 | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 0.5498 | nM | 9.26 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.175 | nM | 8.66 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.236 | nM | 8.37 |
| CHEMBL189584 | PD-173074 | IC50 | = | 12.25 | nM | 7.91 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 12.28 | nM | 7.91 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 24.62 | nM | 7.61 |
| CHEMBL514499 | GW843682X | IC50 | = | 30.52 | nM | 7.51 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 33.5 | nM | 7.47 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 37.16 | nM | 7.43 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 45.09 | nM | 7.35 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 49.53 | nM | 7.30 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 64.03 | nM | 7.19 |
| CHEMBL217354 | — | IC50 | = | 67.64 | nM | 7.17 |
| CHEMBL513909 | BI-2536 | IC50 | = | 74.78 | nM | 7.13 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 102.9 | nM | 6.99 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 189.66 | nM | 6.72 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 296.89 | nM | 6.53 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 356.2 | nM | 6.45 |
| CHEMBL300389 | — | IC50 | = | 587.68 | nM | 6.23 |
| CHEMBL379300 | A-443654 | IC50 | = | 605.82 | nM | 6.22 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 779.09 | nM | 6.11 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 873.37 | nM | 6.06 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 892.97 | nM | 6.05 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 906.74 | nM | 6.04 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 981.31 | nM | 6.01 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1173.72 | nM | 5.93 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 1356.87 | nM | 5.87 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1337.15 | nM | 5.87 |
| CHEMBL585951 | — | IC50 | = | 1343.15 | nM | 5.87 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 1390.42 | nM | 5.86 |
| CHEMBL512504 | — | IC50 | = | 1440.28 | nM | 5.84 |
| CHEMBL202721 | — | IC50 | = | 1675.5 | nM | 5.78 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1769.55 | nM | 5.75 |
| CHEMBL509032 | TAE-684 | IC50 | = | 2115.59 | nM | 5.67 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 2195.96 | nM | 5.66 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 2321.05 | nM | 5.63 |
| CHEMBL379975 | — | IC50 | = | 2768.16 | nM | 5.56 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 2796.81 | nM | 5.55 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3600.64 | nM | 5.44 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3649.43 | nM | 5.44 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3844.88 | nM | 5.42 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 4287.98 | nM | 5.37 |
| CHEMBL64925 | MG-132 | IC50 | = | 6238.49 | nM | 5.21 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 6784.05 | nM | 5.17 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 8012.0 | nM | 5.10 |
| CHEMBL105442 | CI-1040 | IC50 | = | 8263.23 | nM | 5.08 |
| CHEMBL477989 | SB590885 | IC50 | = | 8731.09 | nM | 5.06 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 8690.38 | nM | 5.06 |
| CHEMBL64925 | MG-132 | IC50 | = | 9157.16 | nM | 5.04 |
| CHEMBL2363137 | — | IC50 | = | 9370.39 | nM | 5.03 |