Assay Detail
Functional
CHEMBL2363504
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human NCI-H209 cell growth in a cell viability assay.
126
Total Activities
125
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H209 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 126 | 5.66 | 10.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 10.31 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.54 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 8.21 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.88 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.76 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.74 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.68 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.43 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.31 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.29 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.28 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 7.26 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.06 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.06 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.01 |
| CHEMBL300389 | — | — | 1 | 6.87 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.81 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 6.75 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 6.71 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.69 |
| CHEMBL514499 | GW843682X | — | 1 | 6.65 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.64 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.63 |
| CHEMBL379300 | A-443654 | — | 1 | 6.61 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.58 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.49 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.44 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.39 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.39 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 6.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 0.04843 | nM | 10.31 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.862 | nM | 8.54 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 6.168 | nM | 8.21 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 13.15 | nM | 7.88 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 17.29 | nM | 7.76 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 18.1 | nM | 7.74 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 20.86 | nM | 7.68 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 36.69 | nM | 7.43 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 48.73 | nM | 7.31 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 50.8 | nM | 7.29 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 52.07 | nM | 7.28 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 54.53 | nM | 7.26 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 87.41 | nM | 7.06 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 87.04 | nM | 7.06 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 97.86 | nM | 7.01 |
| CHEMBL300389 | — | IC50 | = | 134.91 | nM | 6.87 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 153.34 | nM | 6.81 |
| CHEMBL1090090 | VX-702 | IC50 | = | 175.8 | nM | 6.75 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 196.52 | nM | 6.71 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 204.6 | nM | 6.69 |
| CHEMBL514499 | GW843682X | IC50 | = | 224.53 | nM | 6.65 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 229.62 | nM | 6.64 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 231.79 | nM | 6.63 |
| CHEMBL379300 | A-443654 | IC50 | = | 246.36 | nM | 6.61 |
| CHEMBL513909 | BI-2536 | IC50 | = | 263.74 | nM | 6.58 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 323.53 | nM | 6.49 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 365.82 | nM | 6.44 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 406.13 | nM | 6.39 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 408.08 | nM | 6.39 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 536.88 | nM | 6.27 |
| CHEMBL379975 | — | IC50 | = | 561.64 | nM | 6.25 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 729.9 | nM | 6.14 |
| CHEMBL573107 | — | IC50 | = | 768.2 | nM | 6.12 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 915.56 | nM | 6.04 |
| CHEMBL202721 | — | IC50 | = | 1166.02 | nM | 5.93 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1206.99 | nM | 5.92 |
| CHEMBL585951 | — | IC50 | = | 1261.72 | nM | 5.90 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 1608.6 | nM | 5.79 |
| CHEMBL939 | GEFITINIB | IC50 | = | 1772.69 | nM | 5.75 |
| CHEMBL38 | TRETINOIN | IC50 | = | 2521.32 | nM | 5.60 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 2912.53 | nM | 5.54 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 3006.73 | nM | 5.52 |
| CHEMBL512504 | — | IC50 | = | 3592.47 | nM | 5.45 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 3676.53 | nM | 5.43 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 4299.99 | nM | 5.37 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 4337.8 | nM | 5.36 |
| CHEMBL189584 | PD-173074 | IC50 | = | 4582.83 | nM | 5.34 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 4785.72 | nM | 5.32 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 4752.74 | nM | 5.32 |
| CHEMBL64925 | MG-132 | IC50 | = | 5193.52 | nM | 5.29 |