Assay Detail
Functional
CHEMBL2363513
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SANGER: Inhibition of human NCI-H2228 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H2228 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.56 | 9.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.50 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.32 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 9.10 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.14 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.10 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.97 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.89 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.87 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.51 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.39 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.31 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.05 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.91 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.45 |
| CHEMBL585951 | — | — | 1 | 6.28 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.22 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.19 |
| CHEMBL217354 | — | — | 1 | 6.18 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.15 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.05 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.04 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.02 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.00 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.90 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.89 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.73 |
| CHEMBL258844 | — | — | 1 | 5.64 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 5.63 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.62 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.314 | nM | 9.50 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.4727 | nM | 9.32 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 0.7963 | nM | 9.10 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 7.253 | nM | 8.14 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 8.004 | nM | 8.10 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.64 | nM | 7.97 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 12.92 | nM | 7.89 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 13.48 | nM | 7.87 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 30.91 | nM | 7.51 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 41.09 | nM | 7.39 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 88.26 | nM | 7.05 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 124.27 | nM | 6.91 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 353.57 | nM | 6.45 |
| CHEMBL585951 | — | IC50 | = | 526.59 | nM | 6.28 |
| CHEMBL803 | CYTARABINE | IC50 | = | 596.51 | nM | 6.22 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 647.99 | nM | 6.19 |
| CHEMBL217354 | — | IC50 | = | 661.73 | nM | 6.18 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 711.51 | nM | 6.15 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 893.39 | nM | 6.05 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 900.95 | nM | 6.04 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 954.65 | nM | 6.02 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 995.89 | nM | 6.00 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1271.67 | nM | 5.90 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1286.4 | nM | 5.89 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1852.03 | nM | 5.73 |
| CHEMBL258844 | — | IC50 | = | 2286.04 | nM | 5.64 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 2315.52 | nM | 5.63 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2383.84 | nM | 5.62 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2655.09 | nM | 5.58 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 3831.26 | nM | 5.42 |
| CHEMBL1190711 | — | IC50 | = | 4338.95 | nM | 5.36 |
| CHEMBL379975 | — | IC50 | = | 4386.36 | nM | 5.36 |
| CHEMBL191384 | — | IC50 | = | 4480.05 | nM | 5.35 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 4640.31 | nM | 5.33 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4977.41 | nM | 5.30 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 7414.58 | nM | 5.13 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 7687.12 | nM | 5.11 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 8157.83 | nM | 5.09 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 8248.85 | nM | 5.08 |
| CHEMBL939 | GEFITINIB | IC50 | = | 9110.81 | nM | 5.04 |
| CHEMBL512504 | — | IC50 | = | 9875.81 | nM | 5.00 |
| CHEMBL573107 | — | IC50 | = | 11492.81 | nM | 4.94 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 13753.08 | nM | 4.86 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 14607.66 | nM | 4.83 |
| CHEMBL135561 | — | IC50 | = | 16117.07 | nM | 4.79 |
| CHEMBL105442 | CI-1040 | IC50 | = | 16515.81 | nM | 4.78 |
| CHEMBL2363137 | — | IC50 | = | 16965.91 | nM | 4.77 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 17307.09 | nM | 4.76 |
| CHEMBL176544 | — | IC50 | = | 18820.73 | nM | 4.72 |