Assay Detail
Functional
CHEMBL2363516
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SANGER: Inhibition of human NCI-H23 cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H23 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.42 | 8.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.44 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.24 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.92 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.91 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.62 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.57 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.39 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.22 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.07 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.68 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.67 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.66 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.62 |
| CHEMBL300389 | — | — | 1 | 6.61 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.61 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.55 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.53 |
| CHEMBL217354 | — | — | 1 | 6.46 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.20 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.19 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.11 |
| CHEMBL379300 | A-443654 | — | 1 | 5.93 |
| CHEMBL64925 | MG-132 | — | 2 | 5.92 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.92 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.92 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.88 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.81 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.81 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.77 |
| CHEMBL379975 | — | — | 1 | 5.63 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.636 | nM | 8.44 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.706 | nM | 8.24 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 12.12 | nM | 7.92 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 12.22 | nM | 7.91 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 23.76 | nM | 7.62 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 26.65 | nM | 7.57 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 40.69 | nM | 7.39 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 60.05 | nM | 7.22 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 84.4 | nM | 7.07 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 211.06 | nM | 6.68 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 216.0 | nM | 6.67 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 219.33 | nM | 6.66 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 240.59 | nM | 6.62 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 247.61 | nM | 6.61 |
| CHEMBL300389 | — | IC50 | = | 244.58 | nM | 6.61 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 283.92 | nM | 6.55 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 293.21 | nM | 6.53 |
| CHEMBL217354 | — | IC50 | = | 347.86 | nM | 6.46 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 628.31 | nM | 6.20 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 641.69 | nM | 6.19 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 778.46 | nM | 6.11 |
| CHEMBL379300 | A-443654 | IC50 | = | 1173.71 | nM | 5.93 |
| CHEMBL64925 | MG-132 | IC50 | = | 1204.1 | nM | 5.92 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1195.72 | nM | 5.92 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1206.61 | nM | 5.92 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 1331.9 | nM | 5.88 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1546.45 | nM | 5.81 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1557.14 | nM | 5.81 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1687.82 | nM | 5.77 |
| CHEMBL379975 | — | IC50 | = | 2321.48 | nM | 5.63 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2466.88 | nM | 5.61 |
| CHEMBL513909 | BI-2536 | IC50 | = | 2807.91 | nM | 5.55 |
| CHEMBL514499 | GW843682X | IC50 | = | 2955.28 | nM | 5.53 |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 3932.2 | nM | 5.41 |
| CHEMBL509032 | TAE-684 | IC50 | = | 4872.27 | nM | 5.31 |
| CHEMBL399530 | — | IC50 | = | 6172.66 | nM | 5.21 |
| CHEMBL64925 | MG-132 | IC50 | = | 6108.75 | nM | 5.21 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 6218.16 | nM | 5.21 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 6544.81 | nM | 5.18 |
| CHEMBL3349342 | — | IC50 | = | 6942.36 | nM | 5.16 |
| CHEMBL515416 | — | IC50 | = | 7317.6 | nM | 5.14 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 9177.46 | nM | 5.04 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 9403.01 | nM | 5.03 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 10644.22 | nM | 4.97 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 11349.71 | nM | 4.95 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 11655.25 | nM | 4.93 |
| CHEMBL393929 | — | IC50 | = | 12415.55 | nM | 4.91 |
| CHEMBL573107 | — | IC50 | = | 12312.51 | nM | 4.91 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 12502.55 | nM | 4.90 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 13186.06 | nM | 4.88 |