Assay Detail
Functional
CHEMBL2363540
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SANGER: Inhibition of human NCI-H661 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H661 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.37 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.09 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.00 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.90 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.87 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.70 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.69 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.52 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.31 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.98 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.95 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.93 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.82 |
| CHEMBL217354 | — | — | 1 | 6.70 |
| CHEMBL585951 | — | — | 1 | 6.30 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.27 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.26 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.21 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.20 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.88 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.84 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.76 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.69 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.67 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.58 |
| CHEMBL2363137 | — | — | 1 | 5.55 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.55 |
| CHEMBL202721 | — | — | 1 | 5.52 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 5.52 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.45 |
| CHEMBL572881 | MOTESANIB | 3.0 | 1 | 5.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL159 | VINBLASTINE | IC50 | = | 8.047 | nM | 8.09 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 10.05 | nM | 8.00 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 12.47 | nM | 7.90 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 13.55 | nM | 7.87 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 19.92 | nM | 7.70 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 20.35 | nM | 7.69 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 30.09 | nM | 7.52 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 49.03 | nM | 7.31 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 104.02 | nM | 6.98 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 111.95 | nM | 6.95 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 116.62 | nM | 6.93 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 151.26 | nM | 6.82 |
| CHEMBL217354 | — | IC50 | = | 201.67 | nM | 6.70 |
| CHEMBL585951 | — | IC50 | = | 501.45 | nM | 6.30 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 541.58 | nM | 6.27 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 551.13 | nM | 6.26 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 611.04 | nM | 6.21 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 637.12 | nM | 6.20 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1304.78 | nM | 5.88 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1447.75 | nM | 5.84 |
| CHEMBL803 | CYTARABINE | IC50 | = | 1734.46 | nM | 5.76 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2023.61 | nM | 5.69 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 2152.95 | nM | 5.67 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2640.85 | nM | 5.58 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 2787.22 | nM | 5.55 |
| CHEMBL2363137 | — | IC50 | = | 2823.01 | nM | 5.55 |
| CHEMBL202721 | — | IC50 | = | 2991.92 | nM | 5.52 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3011.68 | nM | 5.52 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 3562.87 | nM | 5.45 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 4197.0 | nM | 5.38 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 4341.79 | nM | 5.36 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 4500.92 | nM | 5.35 |
| CHEMBL135561 | — | IC50 | = | 5209.94 | nM | 5.28 |
| CHEMBL258844 | — | IC50 | = | 5423.26 | nM | 5.27 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 5428.73 | nM | 5.26 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 6069.4 | nM | 5.22 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 6180.81 | nM | 5.21 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 6451.75 | nM | 5.19 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 7496.39 | nM | 5.12 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 7870.69 | nM | 5.10 |
| CHEMBL939 | GEFITINIB | IC50 | = | 8058.67 | nM | 5.09 |
| CHEMBL1186585 | — | IC50 | = | 10216.43 | nM | 4.99 |
| CHEMBL591429 | PAC-1 | IC50 | = | 10324.76 | nM | 4.99 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 10170.0 | nM | 4.99 |
| CHEMBL191384 | — | IC50 | = | 11173.83 | nM | 4.95 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 12596.58 | nM | 4.90 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 12858.73 | nM | 4.89 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 13551.12 | nM | 4.87 |
| CHEMBL2134202 | — | IC50 | = | 13644.9 | nM | 4.87 |
| CHEMBL105442 | CI-1040 | IC50 | = | 14959.01 | nM | 4.83 |