Assay Detail
Functional
CHEMBL2363541
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SANGER: Inhibition of human NCI-H69 cell growth in a cell viability assay.
122
Total Activities
121
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H69 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 122 | 5.37 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.81 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.20 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.83 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.75 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.31 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.25 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 7.00 |
| CHEMBL64925 | MG-132 | — | 2 | 6.82 |
| CHEMBL514499 | GW843682X | — | 1 | 6.74 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.67 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.57 |
| CHEMBL300389 | — | — | 1 | 6.55 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.51 |
| CHEMBL379300 | A-443654 | — | 1 | 6.50 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.37 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 6.34 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.30 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 6.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.25 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.19 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.10 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.01 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.01 |
| CHEMBL585951 | — | — | 1 | 5.93 |
| CHEMBL512504 | — | — | 1 | 5.92 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.87 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.86 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.81 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.78 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.544 | nM | 8.81 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 6.345 | nM | 8.20 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 14.84 | nM | 7.83 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 17.78 | nM | 7.75 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 48.49 | nM | 7.31 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 56.67 | nM | 7.25 |
| CHEMBL1090090 | VX-702 | IC50 | = | 99.41 | nM | 7.00 |
| CHEMBL64925 | MG-132 | IC50 | = | 151.41 | nM | 6.82 |
| CHEMBL514499 | GW843682X | IC50 | = | 181.13 | nM | 6.74 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 214.51 | nM | 6.67 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 272.01 | nM | 6.57 |
| CHEMBL300389 | — | IC50 | = | 279.82 | nM | 6.55 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 311.44 | nM | 6.51 |
| CHEMBL379300 | A-443654 | IC50 | = | 317.92 | nM | 6.50 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 426.76 | nM | 6.37 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 459.48 | nM | 6.34 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 502.47 | nM | 6.30 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 525.78 | nM | 6.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 568.8 | nM | 6.25 |
| CHEMBL513909 | BI-2536 | IC50 | = | 648.79 | nM | 6.19 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 801.47 | nM | 6.10 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 986.33 | nM | 6.01 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 976.34 | nM | 6.01 |
| CHEMBL585951 | — | IC50 | = | 1182.89 | nM | 5.93 |
| CHEMBL512504 | — | IC50 | = | 1193.91 | nM | 5.92 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 1341.12 | nM | 5.87 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1395.49 | nM | 5.86 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1558.11 | nM | 5.81 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1673.43 | nM | 5.78 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1678.82 | nM | 5.78 |
| CHEMBL38 | TRETINOIN | IC50 | = | 2265.61 | nM | 5.64 |
| CHEMBL573107 | — | IC50 | = | 2716.01 | nM | 5.57 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 3190.65 | nM | 5.50 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3901.78 | nM | 5.41 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 4019.36 | nM | 5.40 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 4517.93 | nM | 5.34 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 4702.75 | nM | 5.33 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 5969.73 | nM | 5.22 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 6442.4 | nM | 5.19 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 6713.8 | nM | 5.17 |
| CHEMBL401930 | — | IC50 | = | 7348.29 | nM | 5.13 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 7667.43 | nM | 5.12 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 8182.34 | nM | 5.09 |
| CHEMBL64925 | MG-132 | IC50 | = | 8792.01 | nM | 5.06 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 9612.06 | nM | 5.02 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 9909.61 | nM | 5.00 |
| CHEMBL1190711 | — | IC50 | = | 10970.75 | nM | 4.96 |
| CHEMBL1242367 | — | IC50 | = | 11912.95 | nM | 4.92 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 12013.92 | nM | 4.92 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 12423.43 | nM | 4.91 |