Assay Detail
Functional
CHEMBL2363544
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SANGER: Inhibition of human NCI-H720 cell growth in a cell viability assay.
122
Total Activities
121
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H720 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 122 | 5.74 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.24 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 8.45 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.16 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.02 |
| CHEMBL1090090 | VX-702 | 2.0 | 1 | 7.77 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.59 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.59 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 7.57 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 7.53 |
| CHEMBL443684 | NAVITOCLAX | 3.0 | 1 | 7.40 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.35 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.31 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.29 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 7.27 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.91 |
| CHEMBL379300 | A-443654 | — | 1 | 6.81 |
| CHEMBL573107 | — | — | 1 | 6.76 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.69 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 6.42 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.40 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.26 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.25 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.20 |
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 5.99 |
| CHEMBL202721 | — | — | 1 | 5.92 |
| CHEMBL509032 | TAE-684 | — | 1 | 5.87 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.81 |
| CHEMBL379975 | — | — | 1 | 5.77 |
| CHEMBL514499 | GW843682X | — | 1 | 5.70 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 5.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.5801 | nM | 9.24 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 3.568 | nM | 8.45 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 6.88 | nM | 8.16 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 9.617 | nM | 8.02 |
| CHEMBL1090090 | VX-702 | IC50 | = | 16.82 | nM | 7.77 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 25.41 | nM | 7.59 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 25.46 | nM | 7.59 |
| CHEMBL939 | GEFITINIB | IC50 | = | 26.92 | nM | 7.57 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 29.38 | nM | 7.53 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 40.11 | nM | 7.40 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 44.69 | nM | 7.35 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 48.53 | nM | 7.31 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 51.11 | nM | 7.29 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 53.25 | nM | 7.27 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 123.72 | nM | 6.91 |
| CHEMBL379300 | A-443654 | IC50 | = | 154.46 | nM | 6.81 |
| CHEMBL573107 | — | IC50 | = | 171.94 | nM | 6.76 |
| CHEMBL513909 | BI-2536 | IC50 | = | 205.25 | nM | 6.69 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 376.79 | nM | 6.42 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 401.91 | nM | 6.40 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 549.62 | nM | 6.26 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 560.18 | nM | 6.25 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 637.07 | nM | 6.20 |
| CHEMBL38 | TRETINOIN | IC50 | = | 1026.21 | nM | 5.99 |
| CHEMBL202721 | — | IC50 | = | 1206.27 | nM | 5.92 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1363.78 | nM | 5.87 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1544.25 | nM | 5.81 |
| CHEMBL379975 | — | IC50 | = | 1702.57 | nM | 5.77 |
| CHEMBL514499 | GW843682X | IC50 | = | 1998.81 | nM | 5.70 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 2062.44 | nM | 5.69 |
| CHEMBL300389 | — | IC50 | = | 2109.32 | nM | 5.68 |
| CHEMBL189584 | PD-173074 | IC50 | = | 2212.83 | nM | 5.66 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 2206.99 | nM | 5.66 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2168.73 | nM | 5.66 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 2265.85 | nM | 5.64 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2316.81 | nM | 5.63 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 2451.61 | nM | 5.61 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2559.72 | nM | 5.59 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 3960.91 | nM | 5.40 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 4536.12 | nM | 5.34 |
| CHEMBL2144069 | — | IC50 | = | 4719.8 | nM | 5.33 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 7193.45 | nM | 5.14 |
| CHEMBL3349342 | — | IC50 | = | 7376.21 | nM | 5.13 |
| CHEMBL180127 | SALUBRINAL | IC50 | = | 7572.68 | nM | 5.12 |
| CHEMBL506871 | VELIPARIB | IC50 | = | 8436.03 | nM | 5.07 |
| CHEMBL105442 | CI-1040 | IC50 | = | 10198.87 | nM | 4.99 |
| CHEMBL64925 | MG-132 | IC50 | = | 10219.8 | nM | 4.99 |
| CHEMBL483847 | — | IC50 | = | 10873.86 | nM | 4.96 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 10954.16 | nM | 4.96 |
| CHEMBL4298697 | — | IC50 | = | 11081.39 | nM | 4.96 |