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Assay Detail

CHEMBL2363556

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Functional
SANGER: Inhibition of human NEC8 cell growth in a cell viability assay.
ChEMBL ↗
137
Total Activities
135
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type NEC8
Confidence 1 — Organism
Curated By Autocuration

Target

NEC8 (CHEMBL2366340) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 137 5.72 9.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 9.25
CHEMBL65 CAMPTOTHECIN -1.0 1 8.51
CHEMBL325041 BORTEZOMIB 3.0 1 8.47
CHEMBL94657 PATUPILONE 3.0 1 8.45
CHEMBL159 VINBLASTINE 4.0 1 8.29
CHEMBL96926 THAPSIGARGIN — 1 7.96
CHEMBL1972860 ELESCLOMOL 3.0 1 7.94
CHEMBL553025 VINORELBINE 4.0 1 7.86
CHEMBL6067492 BLEOMYCIN 4.0 1 7.57
CHEMBL53463 DOXORUBICIN 4.0 1 7.47
CHEMBL888 GEMCITABINE 4.0 1 7.45
CHEMBL2041933 AZD-7762 1.0 1 7.38
CHEMBL514499 GW843682X — 1 7.31
CHEMBL428647 PACLITAXEL 4.0 1 7.28
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.25
CHEMBL1879463 DACTOLISIB 3.0 1 7.17
CHEMBL1079175 MK-2206 2.0 1 7.01
CHEMBL513909 BI-2536 2.0 1 6.98
CHEMBL64925 MG-132 — 2 6.92
CHEMBL27759 ENTINOSTAT 3.0 1 6.87
CHEMBL803 CYTARABINE 4.0 1 6.87
CHEMBL217354 — — 1 6.84
CHEMBL105 MITOMYCIN 4.0 1 6.73
CHEMBL603469 LESTAURTINIB 3.0 1 6.57
CHEMBL34259 METHOTREXATE 4.0 1 6.54
CHEMBL98 VORINOSTAT 4.0 1 6.54
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.40
CHEMBL509032 TAE-684 — 1 6.38
CHEMBL1801204 AZD-8055 1.0 1 6.38
CHEMBL252164 LUMINESPIB 2.0 1 6.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 0.5607 nM 9.25
CHEMBL65 CAMPTOTHECIN IC50 = 3.108 nM 8.51
CHEMBL325041 BORTEZOMIB IC50 = 3.35 nM 8.47
CHEMBL94657 PATUPILONE IC50 = 3.53 nM 8.45
CHEMBL159 VINBLASTINE IC50 = 5.122 nM 8.29
CHEMBL96926 THAPSIGARGIN IC50 = 11.0 nM 7.96
CHEMBL1972860 ELESCLOMOL IC50 = 11.49 nM 7.94
CHEMBL553025 VINORELBINE IC50 = 13.91 nM 7.86
CHEMBL6067492 BLEOMYCIN IC50 = 26.85 nM 7.57
CHEMBL53463 DOXORUBICIN IC50 = 33.61 nM 7.47
CHEMBL888 GEMCITABINE IC50 = 35.37 nM 7.45
CHEMBL2041933 AZD-7762 IC50 = 42.03 nM 7.38
CHEMBL514499 GW843682X IC50 = 48.69 nM 7.31
CHEMBL428647 PACLITAXEL IC50 = 52.86 nM 7.28
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 55.9 nM 7.25
CHEMBL1879463 DACTOLISIB IC50 = 67.24 nM 7.17
CHEMBL1079175 MK-2206 IC50 = 96.51 nM 7.01
CHEMBL513909 BI-2536 IC50 = 105.25 nM 6.98
CHEMBL64925 MG-132 IC50 = 119.95 nM 6.92
CHEMBL803 CYTARABINE IC50 = 134.21 nM 6.87
CHEMBL27759 ENTINOSTAT IC50 = 135.27 nM 6.87
CHEMBL217354 — IC50 = 145.28 nM 6.84
CHEMBL105 MITOMYCIN IC50 = 186.77 nM 6.73
CHEMBL603469 LESTAURTINIB IC50 = 267.96 nM 6.57
CHEMBL34259 METHOTREXATE IC50 = 289.76 nM 6.54
CHEMBL98 VORINOSTAT IC50 = 289.38 nM 6.54
CHEMBL449158 BRYOSTATIN 1 IC50 = 400.26 nM 6.40
CHEMBL509032 TAE-684 IC50 = 412.92 nM 6.38
CHEMBL1801204 AZD-8055 IC50 = 416.95 nM 6.38
CHEMBL252164 LUMINESPIB IC50 = 451.45 nM 6.34
CHEMBL512504 — IC50 = 480.29 nM 6.32
CHEMBL44657 ETOPOSIDE IC50 = 538.95 nM 6.27
CHEMBL189584 PD-173074 IC50 = 562.89 nM 6.25
CHEMBL1256459 TORIN1 IC50 = 561.72 nM 6.25
CHEMBL521851 PICTILISIB IC50 = 653.57 nM 6.18
CHEMBL1289926 AXITINIB IC50 = 721.13 nM 6.14
CHEMBL9470 SHIKONIN IC50 = 839.9 nM 6.08
CHEMBL507361 MIRDAMETINIB IC50 = 935.77 nM 6.03
CHEMBL585951 — IC50 = 1012.37 nM 6.00
CHEMBL191334 NUTLIN-3 IC50 = 1215.72 nM 5.92
CHEMBL176544 — IC50 = 1234.19 nM 5.91
CHEMBL36 PYRIMETHAMINE IC50 = 1501.68 nM 5.82
CHEMBL188678 — IC50 = 1553.5 nM 5.81
CHEMBL573107 — IC50 = 1701.15 nM 5.77
CHEMBL1171837 PONATINIB IC50 = 1789.95 nM 5.75
CHEMBL575448 BMS-754807 IC50 = 1854.75 nM 5.73
CHEMBL608533 MIDOSTAURIN IC50 = 2156.01 nM 5.67
CHEMBL11359 CISPLATIN IC50 = 2520.87 nM 5.60
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 2685.78 nM 5.57
CHEMBL379300 A-443654 IC50 = 3320.59 nM 5.48