Assay Detail
Functional
CHEMBL2363601
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SANGER: Inhibition of human RKO cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RKO |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.93 | 10.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.56 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 10.19 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.01 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.97 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.82 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.79 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.53 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.37 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 8.08 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.98 |
| CHEMBL217354 | — | — | 1 | 7.82 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.81 |
| CHEMBL514499 | GW843682X | — | 1 | 7.77 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.70 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.68 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.65 |
| CHEMBL2144069 | — | — | 1 | 7.42 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.42 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.30 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 7.28 |
| CHEMBL300389 | — | — | 1 | 6.94 |
| CHEMBL585951 | — | — | 1 | 6.93 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.93 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.90 |
| CHEMBL379300 | A-443654 | — | 1 | 6.87 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.87 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.65 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.61 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.02785 | nM | 10.56 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.06474 | nM | 10.19 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.9888 | nM | 9.01 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 1.061 | nM | 8.97 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1.52 | nM | 8.82 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1.61 | nM | 8.79 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.977 | nM | 8.53 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 4.23 | nM | 8.37 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 8.262 | nM | 8.08 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 8.239 | nM | 8.08 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 10.44 | nM | 7.98 |
| CHEMBL217354 | — | IC50 | = | 15.17 | nM | 7.82 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 15.33 | nM | 7.81 |
| CHEMBL514499 | GW843682X | IC50 | = | 17.15 | nM | 7.77 |
| CHEMBL513909 | BI-2536 | IC50 | = | 19.87 | nM | 7.70 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 20.98 | nM | 7.68 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 22.28 | nM | 7.65 |
| CHEMBL2144069 | — | IC50 | = | 37.67 | nM | 7.42 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 38.33 | nM | 7.42 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 50.29 | nM | 7.30 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 52.02 | nM | 7.28 |
| CHEMBL300389 | — | IC50 | = | 114.35 | nM | 6.94 |
| CHEMBL585951 | — | IC50 | = | 117.47 | nM | 6.93 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 117.64 | nM | 6.93 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 125.29 | nM | 6.90 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 135.48 | nM | 6.87 |
| CHEMBL379300 | A-443654 | IC50 | = | 136.17 | nM | 6.87 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 225.71 | nM | 6.65 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 248.38 | nM | 6.61 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 270.3 | nM | 6.57 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 299.49 | nM | 6.52 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 308.13 | nM | 6.51 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 420.17 | nM | 6.38 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 470.75 | nM | 6.33 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 520.19 | nM | 6.28 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 524.24 | nM | 6.28 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 529.66 | nM | 6.28 |
| CHEMBL803 | CYTARABINE | IC50 | = | 598.58 | nM | 6.22 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 677.07 | nM | 6.17 |
| CHEMBL202721 | — | IC50 | = | 706.56 | nM | 6.15 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 868.17 | nM | 6.06 |
| CHEMBL64925 | MG-132 | IC50 | = | 931.76 | nM | 6.03 |
| CHEMBL401930 | — | IC50 | = | 1004.12 | nM | 6.00 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1225.38 | nM | 5.91 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1243.89 | nM | 5.91 |
| CHEMBL3349342 | — | IC50 | = | 1389.21 | nM | 5.86 |
| CHEMBL509032 | TAE-684 | IC50 | = | 1499.22 | nM | 5.82 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 1579.69 | nM | 5.80 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 1871.01 | nM | 5.73 |
| CHEMBL221137 | EMBELIN | IC50 | = | 2006.78 | nM | 5.70 |