Assay Detail
Functional
CHEMBL2363603
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SANGER: Inhibition of human RL95-2 cell growth in a cell viability assay.
54
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RL95-2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 5.96 | 9.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 9.97 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 9.18 |
| CHEMBL1256459 | TORIN1 | — | 1 | 8.49 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.42 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.15 |
| CHEMBL514499 | GW843682X | — | 1 | 7.95 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.76 |
| CHEMBL379300 | A-443654 | — | 1 | 7.64 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.98 |
| CHEMBL300389 | — | — | 1 | 6.75 |
| CHEMBL197603 | — | — | 1 | 6.42 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 6.39 |
| CHEMBL509032 | TAE-684 | — | 1 | 6.30 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 6.22 |
| CHEMBL585951 | — | — | 1 | 6.18 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.14 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.10 |
| CHEMBL401930 | — | — | 1 | 6.09 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.96 |
| CHEMBL213100 | — | — | 1 | 5.88 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 5.78 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.77 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.67 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 5.67 |
| CHEMBL1242367 | — | — | 1 | 5.50 |
| CHEMBL554 | LAPATINIB | 4.0 | 1 | 5.50 |
| CHEMBL1084546 | PF-00562271 | 1.0 | 1 | 5.43 |
| CHEMBL483847 | — | — | 1 | 5.41 |
| CHEMBL2144069 | — | — | 1 | 5.39 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | IC50 | = | 0.1073 | nM | 9.97 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 0.6681 | nM | 9.18 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 3.201 | nM | 8.49 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.793 | nM | 8.42 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 7.132 | nM | 8.15 |
| CHEMBL514499 | GW843682X | IC50 | = | 11.29 | nM | 7.95 |
| CHEMBL513909 | BI-2536 | IC50 | = | 17.38 | nM | 7.76 |
| CHEMBL379300 | A-443654 | IC50 | = | 22.81 | nM | 7.64 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 103.8 | nM | 6.98 |
| CHEMBL300389 | — | IC50 | = | 176.57 | nM | 6.75 |
| CHEMBL197603 | — | IC50 | = | 379.5 | nM | 6.42 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 405.67 | nM | 6.39 |
| CHEMBL509032 | TAE-684 | IC50 | = | 501.12 | nM | 6.30 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 604.94 | nM | 6.22 |
| CHEMBL585951 | — | IC50 | = | 660.37 | nM | 6.18 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 719.73 | nM | 6.14 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 795.72 | nM | 6.10 |
| CHEMBL401930 | — | IC50 | = | 813.48 | nM | 6.09 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 1110.34 | nM | 5.96 |
| CHEMBL213100 | — | IC50 | = | 1324.36 | nM | 5.88 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 1669.02 | nM | 5.78 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 1714.63 | nM | 5.77 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2114.82 | nM | 5.67 |
| CHEMBL535 | SUNITINIB | IC50 | = | 2111.37 | nM | 5.67 |
| CHEMBL1242367 | — | IC50 | = | 3195.22 | nM | 5.50 |
| CHEMBL554 | LAPATINIB | IC50 | = | 3156.7 | nM | 5.50 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 3718.64 | nM | 5.43 |
| CHEMBL483847 | — | IC50 | = | 3927.59 | nM | 5.41 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 4033.2 | nM | 5.39 |
| CHEMBL2144069 | — | IC50 | = | 4101.19 | nM | 5.39 |
| CHEMBL209148 | — | IC50 | = | 4512.03 | nM | 5.35 |
| CHEMBL64925 | MG-132 | IC50 | = | 8108.42 | nM | 5.09 |
| CHEMBL1673039 | — | IC50 | = | 9534.47 | nM | 5.02 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 10670.0 | nM | 4.97 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 15677.37 | nM | 4.80 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 16397.78 | nM | 4.79 |
| CHEMBL1643959 | — | IC50 | = | 16790.73 | nM | 4.78 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 21784.92 | nM | 4.66 |
| CHEMBL515416 | — | IC50 | = | 27528.39 | nM | 4.56 |
| CHEMBL64925 | MG-132 | IC50 | = | 29563.75 | nM | 4.53 |
| CHEMBL941 | IMATINIB | IC50 | = | 50071.05 | nM | 4.30 |
| CHEMBL512504 | — | IC50 | = | 50770.48 | nM | 4.29 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 55394.26 | nM | 4.26 |
| CHEMBL135561 | — | IC50 | = | 58605.17 | nM | 4.23 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 82234.34 | nM | 4.08 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 300246.56 | nM | - |
| CHEMBL472004 | — | IC50 | = | 624255.04 | nM | - |
| CHEMBL4298697 | — | IC50 | = | 164072.93 | nM | - |
| CHEMBL1336 | SORAFENIB | IC50 | = | 136323.13 | nM | - |
| CHEMBL254129 | CYCLOPAMINE | IC50 | = | 460236.74 | nM | - |