Assay Detail
Functional
CHEMBL2363610
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SANGER: Inhibition of human RPMI-8402 cell growth in a cell viability assay.
77
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 77 | 5.74 | 8.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 8.46 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.35 |
| CHEMBL514499 | GW843682X | — | 1 | 8.33 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.28 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.91 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.90 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 7.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.73 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 7.66 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 7.60 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 7.34 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.27 |
| CHEMBL300389 | — | — | 1 | 7.15 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.11 |
| CHEMBL379300 | A-443654 | — | 1 | 6.74 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.57 |
| CHEMBL27759 | ENTINOSTAT | 3.0 | 1 | 6.41 |
| CHEMBL512504 | — | — | 1 | 6.36 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.28 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.24 |
| CHEMBL585951 | — | — | 1 | 6.22 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 5.99 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | — | 1 | 5.89 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.89 |
| CHEMBL9470 | SHIKONIN | — | 1 | 5.82 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.75 |
| CHEMBL1190711 | — | — | 1 | 5.75 |
| CHEMBL535 | SUNITINIB | 4.0 | 1 | 5.63 |
| CHEMBL1242367 | — | — | 1 | 5.46 |
| CHEMBL572878 | TOZASERTIB | 2.0 | 1 | 5.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 3.496 | nM | 8.46 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 4.451 | nM | 8.35 |
| CHEMBL514499 | GW843682X | IC50 | = | 4.669 | nM | 8.33 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 5.227 | nM | 8.28 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 12.56 | nM | 7.90 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 17.13 | nM | 7.77 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 18.58 | nM | 7.73 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 21.77 | nM | 7.66 |
| CHEMBL513909 | BI-2536 | IC50 | = | 25.08 | nM | 7.60 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 45.93 | nM | 7.34 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 53.86 | nM | 7.27 |
| CHEMBL300389 | — | IC50 | = | 70.93 | nM | 7.15 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 77.89 | nM | 7.11 |
| CHEMBL379300 | A-443654 | IC50 | = | 183.65 | nM | 6.74 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 271.09 | nM | 6.57 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 387.01 | nM | 6.41 |
| CHEMBL512504 | — | IC50 | = | 441.61 | nM | 6.36 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 522.07 | nM | 6.28 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 577.66 | nM | 6.24 |
| CHEMBL585951 | — | IC50 | = | 605.24 | nM | 6.22 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 1030.69 | nM | 5.99 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1283.53 | nM | 5.89 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 1284.87 | nM | 5.89 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 1498.31 | nM | 5.82 |
| CHEMBL591429 | PAC-1 | IC50 | = | 1771.31 | nM | 5.75 |
| CHEMBL1190711 | — | IC50 | = | 1767.03 | nM | 5.75 |
| CHEMBL535 | SUNITINIB | IC50 | = | 2336.18 | nM | 5.63 |
| CHEMBL1242367 | — | IC50 | = | 3480.81 | nM | 5.46 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 3586.03 | nM | 5.45 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 3711.96 | nM | 5.43 |
| CHEMBL221137 | EMBELIN | IC50 | = | 4054.37 | nM | 5.39 |
| CHEMBL1673039 | — | IC50 | = | 4504.83 | nM | 5.35 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 4585.6 | nM | 5.34 |
| CHEMBL472940 | — | IC50 | = | 5768.76 | nM | 5.24 |
| CHEMBL515416 | — | IC50 | = | 6643.12 | nM | 5.18 |
| CHEMBL2363137 | — | IC50 | = | 6845.95 | nM | 5.17 |
| CHEMBL36 | PYRIMETHAMINE | IC50 | = | 8116.01 | nM | 5.09 |
| CHEMBL64925 | MG-132 | IC50 | = | 8279.28 | nM | 5.08 |
| CHEMBL191384 | — | IC50 | = | 8657.69 | nM | 5.06 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 8899.26 | nM | 5.05 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 10115.97 | nM | 5.00 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 10373.27 | nM | 4.98 |
| CHEMBL209148 | — | IC50 | = | 10973.34 | nM | 4.96 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 11178.03 | nM | 4.95 |
| CHEMBL2144069 | — | IC50 | = | 11739.5 | nM | 4.93 |
| CHEMBL401930 | — | IC50 | = | 11744.12 | nM | 4.93 |
| CHEMBL14762 | SELICICLIB | IC50 | = | 13626.18 | nM | 4.87 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 13503.15 | nM | 4.87 |
| CHEMBL254129 | CYCLOPAMINE | IC50 | = | 15853.7 | nM | 4.80 |