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Assay Detail

CHEMBL2363613

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Functional
SANGER: Inhibition of human RT-112 cell growth in a cell viability assay.
ChEMBL ↗
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type RT-112
Confidence 1 — Organism
Curated By Autocuration

Target

RT-112 (CHEMBL614145) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 99 5.93 9.89

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL888 GEMCITABINE 4.0 1 9.89
CHEMBL94657 PATUPILONE 3.0 1 9.21
CHEMBL3545252 DOCETAXEL 4.0 1 8.93
CHEMBL159 VINBLASTINE 4.0 1 8.57
CHEMBL553025 VINORELBINE 4.0 1 8.47
CHEMBL96926 THAPSIGARGIN — 1 8.38
CHEMBL252164 LUMINESPIB 2.0 1 8.27
CHEMBL1972860 ELESCLOMOL 3.0 1 7.85
CHEMBL65 CAMPTOTHECIN -1.0 1 7.83
CHEMBL1879463 DACTOLISIB 3.0 1 7.71
CHEMBL53463 DOXORUBICIN 4.0 1 7.48
CHEMBL449158 BRYOSTATIN 1 2.0 1 7.38
CHEMBL1201182 TEMSIROLIMUS 4.0 1 7.33
CHEMBL507361 MIRDAMETINIB 2.0 1 7.31
CHEMBL9470 SHIKONIN — 1 7.15
CHEMBL109480 TANESPIMYCIN 3.0 1 6.85
CHEMBL34259 METHOTREXATE 4.0 1 6.85
CHEMBL105 MITOMYCIN 4.0 1 6.75
CHEMBL1171837 PONATINIB 4.0 1 6.62
CHEMBL189963 PALBOCICLIB 4.0 1 6.49
CHEMBL585951 — — 1 6.47
CHEMBL289228 TIPIFARNIB 3.0 1 6.42
CHEMBL603469 LESTAURTINIB 3.0 1 6.33
CHEMBL2041933 AZD-7762 1.0 1 6.30
CHEMBL803 CYTARABINE 4.0 1 6.30
CHEMBL217354 — — 1 6.27
CHEMBL189584 PD-173074 — 1 6.26
CHEMBL44657 ETOPOSIDE 4.0 1 6.21
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 6.18
CHEMBL575448 BMS-754807 2.0 1 6.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL888 GEMCITABINE IC50 = 0.1273 nM 9.89
CHEMBL94657 PATUPILONE IC50 = 0.6143 nM 9.21
CHEMBL3545252 DOCETAXEL IC50 = 1.187 nM 8.93
CHEMBL159 VINBLASTINE IC50 = 2.708 nM 8.57
CHEMBL553025 VINORELBINE IC50 = 3.371 nM 8.47
CHEMBL96926 THAPSIGARGIN IC50 = 4.217 nM 8.38
CHEMBL252164 LUMINESPIB IC50 = 5.353 nM 8.27
CHEMBL1972860 ELESCLOMOL IC50 = 14.23 nM 7.85
CHEMBL65 CAMPTOTHECIN IC50 = 14.88 nM 7.83
CHEMBL1879463 DACTOLISIB IC50 = 19.66 nM 7.71
CHEMBL53463 DOXORUBICIN IC50 = 32.92 nM 7.48
CHEMBL449158 BRYOSTATIN 1 IC50 = 41.53 nM 7.38
CHEMBL1201182 TEMSIROLIMUS IC50 = 47.09 nM 7.33
CHEMBL507361 MIRDAMETINIB IC50 = 48.82 nM 7.31
CHEMBL9470 SHIKONIN IC50 = 70.37 nM 7.15
CHEMBL109480 TANESPIMYCIN IC50 = 140.35 nM 6.85
CHEMBL34259 METHOTREXATE IC50 = 142.31 nM 6.85
CHEMBL105 MITOMYCIN IC50 = 177.98 nM 6.75
CHEMBL1171837 PONATINIB IC50 = 237.95 nM 6.62
CHEMBL189963 PALBOCICLIB IC50 = 321.05 nM 6.49
CHEMBL585951 — IC50 = 337.17 nM 6.47
CHEMBL289228 TIPIFARNIB IC50 = 381.76 nM 6.42
CHEMBL603469 LESTAURTINIB IC50 = 464.05 nM 6.33
CHEMBL2041933 AZD-7762 IC50 = 499.21 nM 6.30
CHEMBL803 CYTARABINE IC50 = 501.93 nM 6.30
CHEMBL217354 — IC50 = 534.54 nM 6.27
CHEMBL189584 PD-173074 IC50 = 547.01 nM 6.26
CHEMBL44657 ETOPOSIDE IC50 = 620.53 nM 6.21
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 665.87 nM 6.18
CHEMBL575448 BMS-754807 IC50 = 751.08 nM 6.12
CHEMBL1801204 AZD-8055 IC50 = 849.37 nM 6.07
CHEMBL1084546 PF-00562271 IC50 = 984.6 nM 6.01
CHEMBL608533 MIDOSTAURIN IC50 = 974.83 nM 6.01
CHEMBL558642 GSK-650394 IC50 = 1027.82 nM 5.99
CHEMBL477772 PAZOPANIB IC50 = 1103.76 nM 5.96
CHEMBL572881 MOTESANIB IC50 = 1585.47 nM 5.80
CHEMBL98 VORINOSTAT IC50 = 1592.84 nM 5.80
CHEMBL105442 CI-1040 IC50 = 1589.52 nM 5.80
CHEMBL3349342 — IC50 = 1587.49 nM 5.80
CHEMBL1289926 AXITINIB IC50 = 2134.24 nM 5.67
CHEMBL1614701 SELUMETINIB IC50 = 2260.46 nM 5.65
CHEMBL6067492 BLEOMYCIN IC50 = 2319.57 nM 5.63
CHEMBL202721 — IC50 = 2660.06 nM 5.58
CHEMBL1079175 MK-2206 IC50 = 3523.88 nM 5.45
CHEMBL577784 BX-795 IC50 = 4006.96 nM 5.40
CHEMBL591429 PAC-1 IC50 = 4046.75 nM 5.39
CHEMBL379975 — IC50 = 4171.71 nM 5.38
CHEMBL939 GEFITINIB IC50 = 5902.45 nM 5.23
CHEMBL2363137 — IC50 = 6105.15 nM 5.21
CHEMBL399530 — IC50 = 6391.18 nM 5.19