Assay Detail
Functional
CHEMBL2363619
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human S-117 cell growth in a cell viability assay.
99
Total Activities
98
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | S-117 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 99 | 5.51 | 8.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.31 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.25 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 8.23 |
| CHEMBL2363137 | — | — | 1 | 8.06 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.54 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.39 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.12 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.11 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.98 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 6.90 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.69 |
| CHEMBL217354 | — | — | 1 | 6.67 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.43 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.41 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.23 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 6.04 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.98 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.95 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.77 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 5.60 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.53 |
| CHEMBL221137 | EMBELIN | — | 1 | 5.44 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.38 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.34 |
| CHEMBL259181 | — | — | 1 | 5.31 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.28 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.27 |
| CHEMBL577784 | BX-795 | — | 1 | 5.26 |
| CHEMBL585951 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 4.855 | nM | 8.31 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 5.576 | nM | 8.25 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 5.923 | nM | 8.23 |
| CHEMBL2363137 | — | IC50 | = | 8.712 | nM | 8.06 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 27.41 | nM | 7.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 29.06 | nM | 7.54 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 40.92 | nM | 7.39 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 76.27 | nM | 7.12 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 78.15 | nM | 7.11 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 105.3 | nM | 6.98 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 126.74 | nM | 6.90 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 205.64 | nM | 6.69 |
| CHEMBL217354 | — | IC50 | = | 213.29 | nM | 6.67 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 368.22 | nM | 6.43 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 387.1 | nM | 6.41 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 592.44 | nM | 6.23 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 921.31 | nM | 6.04 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1116.87 | nM | 5.95 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1705.04 | nM | 5.77 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 2508.45 | nM | 5.60 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2924.22 | nM | 5.53 |
| CHEMBL221137 | EMBELIN | IC50 | = | 3629.58 | nM | 5.44 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 4220.24 | nM | 5.38 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 4525.21 | nM | 5.34 |
| CHEMBL259181 | — | IC50 | = | 4881.45 | nM | 5.31 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 5312.5 | nM | 5.28 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 5369.76 | nM | 5.27 |
| CHEMBL577784 | BX-795 | IC50 | = | 5451.87 | nM | 5.26 |
| CHEMBL585951 | — | IC50 | = | 6297.41 | nM | 5.20 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 6303.27 | nM | 5.20 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 6502.67 | nM | 5.19 |
| CHEMBL191384 | — | IC50 | = | 6936.5 | nM | 5.16 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 7579.24 | nM | 5.12 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 8253.53 | nM | 5.08 |
| CHEMBL3349342 | — | IC50 | = | 8540.2 | nM | 5.07 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 9594.74 | nM | 5.02 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 9801.81 | nM | 5.01 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 10816.64 | nM | 4.97 |
| CHEMBL105442 | CI-1040 | IC50 | = | 11489.56 | nM | 4.94 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 11880.83 | nM | 4.92 |
| CHEMBL102714 | SB-216763 | IC50 | = | 16402.18 | nM | 4.79 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 17285.17 | nM | 4.76 |
| CHEMBL379975 | — | IC50 | = | 24185.81 | nM | 4.62 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 24111.38 | nM | 4.62 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 23765.14 | nM | 4.62 |
| CHEMBL135561 | — | IC50 | = | 26287.54 | nM | 4.58 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 27757.14 | nM | 4.56 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 29385.7 | nM | 4.53 |
| CHEMBL472940 | — | IC50 | = | 31448.46 | nM | 4.50 |