Assay Detail
Functional
CHEMBL2363644
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SANGER: Inhibition of human SK-MEL-1 cell growth in a cell viability assay.
130
Total Activities
129
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 130 | 5.17 | 7.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.45 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.29 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 7.24 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.17 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.57 |
| CHEMBL2144069 | — | — | 1 | 6.42 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 6.30 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 6.29 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.28 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.26 |
| CHEMBL514499 | GW843682X | — | 1 | 6.08 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.02 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 5.92 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.91 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.88 |
| CHEMBL585951 | — | — | 1 | 5.88 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 5.82 |
| CHEMBL1256459 | TORIN1 | — | 1 | 5.78 |
| CHEMBL188678 | — | — | 1 | 5.75 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 5.72 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.64 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 5.63 |
| CHEMBL512504 | — | — | 1 | 5.58 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 5.54 |
| CHEMBL255863 | NILOTINIB | 4.0 | 1 | 5.46 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 5.43 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 5.39 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 5.38 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.28 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 35.17 | nM | 7.45 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 51.29 | nM | 7.29 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 67.32 | nM | 7.17 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 271.11 | nM | 6.57 |
| CHEMBL2144069 | — | IC50 | = | 383.62 | nM | 6.42 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 500.44 | nM | 6.30 |
| CHEMBL939 | GEFITINIB | IC50 | = | 510.99 | nM | 6.29 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 523.27 | nM | 6.28 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 551.2 | nM | 6.26 |
| CHEMBL514499 | GW843682X | IC50 | = | 832.06 | nM | 6.08 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 948.83 | nM | 6.02 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 1205.95 | nM | 5.92 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1234.19 | nM | 5.91 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1306.79 | nM | 5.88 |
| CHEMBL585951 | — | IC50 | = | 1331.22 | nM | 5.88 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 1518.19 | nM | 5.82 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 1648.77 | nM | 5.78 |
| CHEMBL188678 | — | IC50 | = | 1794.79 | nM | 5.75 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 1888.15 | nM | 5.72 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 2281.81 | nM | 5.64 |
| CHEMBL513909 | BI-2536 | IC50 | = | 2320.47 | nM | 5.63 |
| CHEMBL512504 | — | IC50 | = | 2610.66 | nM | 5.58 |
| CHEMBL803 | CYTARABINE | IC50 | = | 2902.49 | nM | 5.54 |
| CHEMBL255863 | NILOTINIB | IC50 | = | 3430.29 | nM | 5.46 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3670.91 | nM | 5.43 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 4035.18 | nM | 5.39 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 4186.95 | nM | 5.38 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 5290.44 | nM | 5.28 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6708.96 | nM | 5.17 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 8131.66 | nM | 5.09 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 8329.8 | nM | 5.08 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 8823.98 | nM | 5.05 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 9191.36 | nM | 5.04 |
| CHEMBL240954 | — | IC50 | = | 9049.28 | nM | 5.04 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 10783.79 | nM | 4.97 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 11764.81 | nM | 4.93 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 11628.86 | nM | 4.93 |
| CHEMBL506871 | VELIPARIB | IC50 | = | 12466.26 | nM | 4.90 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 13713.48 | nM | 4.86 |
| CHEMBL521686 | OLAPARIB | IC50 | = | 13934.73 | nM | 4.86 |
| CHEMBL379975 | — | IC50 | = | 14202.85 | nM | 4.85 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 14663.58 | nM | 4.83 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 17007.15 | nM | 4.77 |
| CHEMBL189584 | PD-173074 | IC50 | = | 17712.7 | nM | 4.75 |
| CHEMBL1190711 | — | IC50 | = | 17686.01 | nM | 4.75 |
| CHEMBL300389 | — | IC50 | = | 19467.82 | nM | 4.71 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 20608.32 | nM | 4.69 |
| CHEMBL103667 | DORAMAPIMOD | IC50 | = | 20368.33 | nM | 4.69 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 20783.6 | nM | 4.68 |