Assay Detail
Functional
CHEMBL2363647
Review assay metadata, readout intent, target linkage, and publication context from the same page.
SANGER: Inhibition of human SK-MEL-28 cell growth in a cell viability assay.
94
Total Activities
94
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | SK-MEL-28 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 94 | 5.38 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.82 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.69 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.77 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.77 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.10 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.95 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.95 |
| CHEMBL3349342 | — | — | 1 | 6.94 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.88 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 6.52 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.49 |
| CHEMBL2363137 | — | — | 1 | 6.45 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.44 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.25 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.21 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.18 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.10 |
| CHEMBL1230020 | PLX-4720 | — | 1 | 5.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.91 |
| CHEMBL217354 | — | — | 1 | 5.86 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.81 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 5.72 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 5.66 |
| CHEMBL573107 | — | — | 1 | 5.28 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 5.21 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 5.13 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 5.13 |
| CHEMBL189584 | PD-173074 | — | 1 | 5.13 |
| CHEMBL221137 | EMBELIN | — | 1 | 5.07 |
| CHEMBL512504 | — | — | 1 | 5.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1.519 | nM | 8.82 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.026 | nM | 8.69 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 17.04 | nM | 7.77 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 17.13 | nM | 7.77 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 79.74 | nM | 7.10 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 111.55 | nM | 6.95 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 113.21 | nM | 6.95 |
| CHEMBL3349342 | — | IC50 | = | 114.9 | nM | 6.94 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 130.55 | nM | 6.88 |
| CHEMBL105442 | CI-1040 | IC50 | = | 304.09 | nM | 6.52 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 326.51 | nM | 6.49 |
| CHEMBL2363137 | — | IC50 | = | 354.56 | nM | 6.45 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 366.09 | nM | 6.44 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 559.1 | nM | 6.25 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 615.39 | nM | 6.21 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 659.83 | nM | 6.18 |
| CHEMBL803 | CYTARABINE | IC50 | = | 798.73 | nM | 6.10 |
| CHEMBL1230020 | PLX-4720 | IC50 | = | 1045.69 | nM | 5.98 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1232.21 | nM | 5.91 |
| CHEMBL217354 | — | IC50 | = | 1389.84 | nM | 5.86 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1560.85 | nM | 5.81 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 1911.24 | nM | 5.72 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 2180.98 | nM | 5.66 |
| CHEMBL573107 | — | IC50 | = | 5203.13 | nM | 5.28 |
| CHEMBL939 | GEFITINIB | IC50 | = | 6209.67 | nM | 5.21 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 7394.01 | nM | 5.13 |
| CHEMBL189584 | PD-173074 | IC50 | = | 7378.19 | nM | 5.13 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 7407.98 | nM | 5.13 |
| CHEMBL221137 | EMBELIN | IC50 | = | 8483.92 | nM | 5.07 |
| CHEMBL512504 | — | IC50 | = | 8424.41 | nM | 5.07 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 9535.96 | nM | 5.02 |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 9618.93 | nM | 5.02 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 10019.32 | nM | 5.00 |
| CHEMBL591429 | PAC-1 | IC50 | = | 10206.86 | nM | 4.99 |
| CHEMBL188678 | — | IC50 | = | 10820.19 | nM | 4.97 |
| CHEMBL379975 | — | IC50 | = | 11706.08 | nM | 4.93 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 11976.42 | nM | 4.92 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 12765.87 | nM | 4.89 |
| CHEMBL176544 | — | IC50 | = | 14283.11 | nM | 4.84 |
| CHEMBL222102 | KU-55933 | IC50 | = | 17047.54 | nM | 4.77 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 18973.1 | nM | 4.72 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 19336.28 | nM | 4.71 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 20376.07 | nM | 4.69 |
| CHEMBL577784 | BX-795 | IC50 | = | 21251.19 | nM | 4.67 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 21686.28 | nM | 4.66 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 22208.34 | nM | 4.65 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 34809.98 | nM | 4.46 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 35537.7 | nM | 4.45 |
| CHEMBL38 | TRETINOIN | IC50 | = | 35356.92 | nM | 4.45 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 35956.22 | nM | 4.44 |