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Assay Detail

CHEMBL2363672

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
SANGER: Inhibition of human SR cell growth in a cell viability assay.
ChEMBL ↗
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SR
Confidence 1 — Organism
Curated By Autocuration

Target

SR (CHEMBL614300) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 78 5.99 9.86

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL220241 GSK-269962A — 1 9.86
CHEMBL325041 BORTEZOMIB 3.0 1 8.90
CHEMBL888 GEMCITABINE 4.0 1 8.67
CHEMBL509032 TAE-684 — 1 8.56
CHEMBL94657 PATUPILONE 3.0 1 8.44
CHEMBL553025 VINORELBINE 4.0 1 8.23
CHEMBL428647 PACLITAXEL 4.0 1 7.99
CHEMBL413 SIROLIMUS 4.0 1 7.94
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.91
CHEMBL105 MITOMYCIN 4.0 1 7.87
CHEMBL514499 GW843682X — 1 7.84
CHEMBL53463 DOXORUBICIN 4.0 1 7.61
CHEMBL300389 — — 1 7.59
CHEMBL252164 LUMINESPIB 2.0 1 7.55
CHEMBL6067492 BLEOMYCIN 4.0 1 7.53
CHEMBL1256459 TORIN1 — 1 7.20
CHEMBL512504 — — 1 6.94
CHEMBL585951 — — 1 6.91
CHEMBL513909 BI-2536 2.0 1 6.91
CHEMBL601719 CRIZOTINIB 4.0 1 6.90
CHEMBL9470 SHIKONIN — 1 6.85
CHEMBL379300 A-443654 — 1 6.74
CHEMBL572878 TOZASERTIB 2.0 1 6.61
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.46
CHEMBL27759 ENTINOSTAT 3.0 1 6.46
CHEMBL608533 MIDOSTAURIN 4.0 1 6.44
CHEMBL44657 ETOPOSIDE 4.0 1 6.35
CHEMBL1190711 — — 1 6.26
CHEMBL392695 S-TRITYL-L-CYSTEINE — 1 6.14
CHEMBL535 SUNITINIB 4.0 1 5.81

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL220241 GSK-269962A IC50 = 0.1371 nM 9.86
CHEMBL325041 BORTEZOMIB IC50 = 1.255 nM 8.90
CHEMBL888 GEMCITABINE IC50 = 2.121 nM 8.67
CHEMBL509032 TAE-684 IC50 = 2.765 nM 8.56
CHEMBL94657 PATUPILONE IC50 = 3.652 nM 8.44
CHEMBL553025 VINORELBINE IC50 = 5.842 nM 8.23
CHEMBL428647 PACLITAXEL IC50 = 10.26 nM 7.99
CHEMBL413 SIROLIMUS IC50 = 11.45 nM 7.94
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 12.35 nM 7.91
CHEMBL105 MITOMYCIN IC50 = 13.46 nM 7.87
CHEMBL514499 GW843682X IC50 = 14.5 nM 7.84
CHEMBL53463 DOXORUBICIN IC50 = 24.41 nM 7.61
CHEMBL300389 — IC50 = 25.51 nM 7.59
CHEMBL252164 LUMINESPIB IC50 = 27.85 nM 7.55
CHEMBL6067492 BLEOMYCIN IC50 = 29.67 nM 7.53
CHEMBL1256459 TORIN1 IC50 = 63.74 nM 7.20
CHEMBL512504 — IC50 = 113.87 nM 6.94
CHEMBL585951 — IC50 = 122.12 nM 6.91
CHEMBL513909 BI-2536 IC50 = 124.41 nM 6.91
CHEMBL601719 CRIZOTINIB IC50 = 126.31 nM 6.90
CHEMBL9470 SHIKONIN IC50 = 140.73 nM 6.85
CHEMBL379300 A-443654 IC50 = 183.83 nM 6.74
CHEMBL572878 TOZASERTIB IC50 = 245.64 nM 6.61
CHEMBL449158 BRYOSTATIN 1 IC50 = 351.11 nM 6.46
CHEMBL27759 ENTINOSTAT IC50 = 342.61 nM 6.46
CHEMBL608533 MIDOSTAURIN IC50 = 365.71 nM 6.44
CHEMBL44657 ETOPOSIDE IC50 = 442.65 nM 6.35
CHEMBL1190711 — IC50 = 548.1 nM 6.26
CHEMBL392695 S-TRITYL-L-CYSTEINE IC50 = 718.13 nM 6.14
CHEMBL535 SUNITINIB IC50 = 1545.72 nM 5.81
CHEMBL135561 — IC50 = 1672.27 nM 5.78
CHEMBL289228 TIPIFARNIB IC50 = 1790.96 nM 5.75
CHEMBL191384 — IC50 = 1875.18 nM 5.73
CHEMBL401930 — IC50 = 2054.65 nM 5.69
CHEMBL96926 THAPSIGARGIN IC50 = 2620.76 nM 5.58
CHEMBL64925 MG-132 IC50 = 4300.2 nM 5.37
CHEMBL5416410 DASATINIB IC50 = 4499.54 nM 5.35
CHEMBL92309 — IC50 = 4579.46 nM 5.34
CHEMBL1171837 PONATINIB IC50 = 4700.48 nM 5.33
CHEMBL2363137 — IC50 = 4954.72 nM 5.30
CHEMBL472940 — IC50 = 5372.56 nM 5.27
CHEMBL1084546 PF-00562271 IC50 = 5536.45 nM 5.26
CHEMBL1336 SORAFENIB IC50 = 6006.78 nM 5.22
CHEMBL1673039 — IC50 = 6475.74 nM 5.19
CHEMBL217092 SARACATINIB IC50 = 6588.07 nM 5.18
CHEMBL2144069 — IC50 = 7649.18 nM 5.12
CHEMBL477772 PAZOPANIB IC50 = 8702.02 nM 5.06
CHEMBL575448 BMS-754807 IC50 = 9823.4 nM 5.01
CHEMBL197603 — IC50 = 11058.4 nM 4.96
CHEMBL64925 MG-132 IC50 = 11018.49 nM 4.96