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Assay Detail

CHEMBL2363689

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Functional
SANGER: Inhibition of human SW756 cell growth in a cell viability assay.
ChEMBL ↗
97
Total Activities
96
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SW756
Confidence 1 — Organism
Curated By Autocuration

Target

SW756 (CHEMBL1075594) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 97 5.66 8.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3545252 DOCETAXEL 4.0 1 8.66
CHEMBL65 CAMPTOTHECIN -1.0 1 8.38
CHEMBL1972860 ELESCLOMOL 3.0 1 8.38
CHEMBL96926 THAPSIGARGIN — 1 7.89
CHEMBL159 VINBLASTINE 4.0 1 7.83
CHEMBL507361 MIRDAMETINIB 2.0 1 7.46
CHEMBL2041933 AZD-7762 1.0 1 7.45
CHEMBL2107358 OBATOCLAX MESYLATE 3.0 1 7.42
CHEMBL94657 PATUPILONE 3.0 1 7.41
CHEMBL252164 LUMINESPIB 2.0 1 7.38
CHEMBL888 GEMCITABINE 4.0 1 7.34
CHEMBL449158 BRYOSTATIN 1 2.0 1 6.98
CHEMBL217354 — — 1 6.95
CHEMBL288441 BOSUTINIB 4.0 1 6.85
CHEMBL553025 VINORELBINE 4.0 1 6.83
CHEMBL53463 DOXORUBICIN 4.0 1 6.56
CHEMBL109480 TANESPIMYCIN 3.0 1 6.36
CHEMBL176544 — — 1 6.36
CHEMBL1201182 TEMSIROLIMUS 4.0 1 6.29
CHEMBL1879463 DACTOLISIB 3.0 1 6.26
CHEMBL105 MITOMYCIN 4.0 1 6.22
CHEMBL603469 LESTAURTINIB 3.0 1 6.20
CHEMBL803 CYTARABINE 4.0 1 6.14
CHEMBL9470 SHIKONIN — 1 6.12
CHEMBL1289926 AXITINIB 4.0 1 6.00
CHEMBL3349342 — — 1 5.91
CHEMBL585951 — — 1 5.69
CHEMBL2363137 — — 1 5.53
CHEMBL44657 ETOPOSIDE 4.0 1 5.53
CHEMBL98 VORINOSTAT 4.0 1 5.48

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3545252 DOCETAXEL IC50 = 2.161 nM 8.66
CHEMBL65 CAMPTOTHECIN IC50 = 4.211 nM 8.38
CHEMBL1972860 ELESCLOMOL IC50 = 4.131 nM 8.38
CHEMBL96926 THAPSIGARGIN IC50 = 12.75 nM 7.89
CHEMBL159 VINBLASTINE IC50 = 14.7 nM 7.83
CHEMBL507361 MIRDAMETINIB IC50 = 34.45 nM 7.46
CHEMBL2041933 AZD-7762 IC50 = 35.79 nM 7.45
CHEMBL2107358 OBATOCLAX MESYLATE IC50 = 38.21 nM 7.42
CHEMBL94657 PATUPILONE IC50 = 38.94 nM 7.41
CHEMBL252164 LUMINESPIB IC50 = 41.57 nM 7.38
CHEMBL888 GEMCITABINE IC50 = 45.14 nM 7.34
CHEMBL449158 BRYOSTATIN 1 IC50 = 105.34 nM 6.98
CHEMBL217354 — IC50 = 112.36 nM 6.95
CHEMBL288441 BOSUTINIB IC50 = 140.24 nM 6.85
CHEMBL553025 VINORELBINE IC50 = 148.38 nM 6.83
CHEMBL53463 DOXORUBICIN IC50 = 274.78 nM 6.56
CHEMBL109480 TANESPIMYCIN IC50 = 441.83 nM 6.36
CHEMBL176544 — IC50 = 439.74 nM 6.36
CHEMBL1201182 TEMSIROLIMUS IC50 = 507.18 nM 6.29
CHEMBL1879463 DACTOLISIB IC50 = 554.96 nM 6.26
CHEMBL105 MITOMYCIN IC50 = 596.91 nM 6.22
CHEMBL603469 LESTAURTINIB IC50 = 629.76 nM 6.20
CHEMBL803 CYTARABINE IC50 = 719.42 nM 6.14
CHEMBL9470 SHIKONIN IC50 = 761.77 nM 6.12
CHEMBL1289926 AXITINIB IC50 = 998.46 nM 6.00
CHEMBL3349342 — IC50 = 1229.64 nM 5.91
CHEMBL585951 — IC50 = 2059.83 nM 5.69
CHEMBL2363137 — IC50 = 2965.96 nM 5.53
CHEMBL44657 ETOPOSIDE IC50 = 2980.46 nM 5.53
CHEMBL98 VORINOSTAT IC50 = 3296.29 nM 5.48
CHEMBL1801204 AZD-8055 IC50 = 4691.35 nM 5.33
CHEMBL1173655 AFATINIB IC50 = 6911.76 nM 5.16
CHEMBL443684 NAVITOCLAX IC50 = 7783.33 nM 5.11
CHEMBL11359 CISPLATIN IC50 = 9262.65 nM 5.03
CHEMBL573107 — IC50 = 9553.61 nM 5.02
CHEMBL105442 CI-1040 IC50 = 11215.44 nM 4.95
CHEMBL6067492 BLEOMYCIN IC50 = 11375.66 nM 4.94
CHEMBL1079175 MK-2206 IC50 = 11529.44 nM 4.94
CHEMBL289228 TIPIFARNIB IC50 = 13620.96 nM 4.87
CHEMBL34259 METHOTREXATE IC50 = 13860.85 nM 4.86
CHEMBL521851 PICTILISIB IC50 = 13724.64 nM 4.86
CHEMBL577784 BX-795 IC50 = 14035.42 nM 4.85
CHEMBL2137530 SERDEMETAN IC50 = 15264.73 nM 4.82
CHEMBL572881 MOTESANIB IC50 = 18076.94 nM 4.74
CHEMBL202721 — IC50 = 18685.62 nM 4.73
CHEMBL393929 — IC50 = 19135.06 nM 4.72
CHEMBL1614701 SELUMETINIB IC50 = 21215.56 nM 4.67
CHEMBL1023 BEXAROTENE IC50 = 24253.53 nM 4.62
CHEMBL399530 — IC50 = 28126.47 nM 4.55
CHEMBL608533 MIDOSTAURIN IC50 = 29286.6 nM 4.53