Assay Detail
Functional
CHEMBL2363732
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SANGER: Inhibition of human A549 cell growth in a cell viability assay.
61
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 61 | 5.93 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 9.52 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 9.05 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 8.30 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 8.10 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.99 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 7.85 |
| CHEMBL217354 | — | — | 1 | 7.85 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.71 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 7.70 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.30 |
| CHEMBL3349342 | — | — | 1 | 6.94 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 6.71 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.71 |
| CHEMBL1614701 | SELUMETINIB | 4.0 | 1 | 6.67 |
| CHEMBL105442 | CI-1040 | 2.0 | 1 | 5.92 |
| CHEMBL189963 | PALBOCICLIB | 4.0 | 1 | 5.89 |
| CHEMBL573107 | — | — | 1 | 5.88 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.85 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.83 |
| CHEMBL577784 | BX-795 | — | 1 | 5.67 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.61 |
| CHEMBL202721 | — | — | 1 | 5.58 |
| CHEMBL191334 | NUTLIN-3 | — | 1 | 5.44 |
| CHEMBL399530 | — | — | 1 | 5.38 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 5.21 |
| CHEMBL379975 | — | — | 1 | 5.11 |
| CHEMBL188678 | — | — | 1 | 5.04 |
| CHEMBL1079175 | MK-2206 | 2.0 | 1 | 4.98 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 4.95 |
| CHEMBL393929 | — | — | 1 | 4.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 0.3029 | nM | 9.52 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 0.8816 | nM | 9.05 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 4.954 | nM | 8.30 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 7.893 | nM | 8.10 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 10.14 | nM | 7.99 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 14.09 | nM | 7.85 |
| CHEMBL217354 | — | IC50 | = | 14.09 | nM | 7.85 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 20.19 | nM | 7.70 |
| CHEMBL803 | CYTARABINE | IC50 | = | 49.66 | nM | 7.30 |
| CHEMBL3349342 | — | IC50 | = | 115.63 | nM | 6.94 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 194.02 | nM | 6.71 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 195.5 | nM | 6.71 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 214.13 | nM | 6.67 |
| CHEMBL105442 | CI-1040 | IC50 | = | 1195.76 | nM | 5.92 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1293.99 | nM | 5.89 |
| CHEMBL573107 | — | IC50 | = | 1309.55 | nM | 5.88 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1399.7 | nM | 5.85 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1488.33 | nM | 5.83 |
| CHEMBL577784 | BX-795 | IC50 | = | 2138.08 | nM | 5.67 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 2448.93 | nM | 5.61 |
| CHEMBL202721 | — | IC50 | = | 2640.47 | nM | 5.58 |
| CHEMBL191334 | NUTLIN-3 | IC50 | = | 3635.52 | nM | 5.44 |
| CHEMBL399530 | — | IC50 | = | 4166.06 | nM | 5.38 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 6125.53 | nM | 5.21 |
| CHEMBL379975 | — | IC50 | = | 7748.03 | nM | 5.11 |
| CHEMBL188678 | — | IC50 | = | 9096.12 | nM | 5.04 |
| CHEMBL1079175 | MK-2206 | IC50 | = | 10397.34 | nM | 4.98 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 11247.75 | nM | 4.95 |
| CHEMBL393929 | — | IC50 | = | 11206.05 | nM | 4.95 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 11589.88 | nM | 4.94 |
| CHEMBL1289926 | AXITINIB | IC50 | = | 12328.47 | nM | 4.91 |
| CHEMBL939 | GEFITINIB | IC50 | = | 14471.16 | nM | 4.84 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 18833.5 | nM | 4.72 |
| CHEMBL1186585 | — | IC50 | = | 20614.26 | nM | 4.69 |
| CHEMBL1090090 | VX-702 | IC50 | = | 21281.07 | nM | 4.67 |
| CHEMBL2134202 | — | IC50 | = | 21849.11 | nM | 4.66 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 21690.12 | nM | 4.66 |
| CHEMBL38 | TRETINOIN | IC50 | = | 29045.98 | nM | 4.54 |
| CHEMBL222102 | KU-55933 | IC50 | = | 43931.03 | nM | 4.36 |
| CHEMBL1173055 | RUCAPARIB | IC50 | = | 71158.02 | nM | 4.15 |
| CHEMBL176544 | — | IC50 | = | 73677.69 | nM | 4.13 |
| CHEMBL189584 | PD-173074 | IC50 | = | 96462.85 | nM | 4.02 |
| CHEMBL848 | LENALIDOMIDE | IC50 | = | 367622.28 | nM | - |
| CHEMBL1431 | METFORMIN | IC50 | = | 4535624.23 | nM | - |
| CHEMBL483849 | — | IC50 | = | 30711148.16 | nM | - |
| CHEMBL443684 | NAVITOCLAX | IC50 | = | 130484.44 | nM | - |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 234642.72 | nM | - |
| CHEMBL255863 | NILOTINIB | IC50 | = | 185551.41 | nM | - |
| CHEMBL1090771 | AVAGACESTAT | IC50 | = | 101816.18 | nM | - |