Assay Detail
Functional
CHEMBL2363748
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SANGER: Inhibition of human BB49-HNC cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BB49-HNC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.32 | 9.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.19 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.67 |
| CHEMBL220241 | GSK-269962A | — | 1 | 8.10 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.97 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.90 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 7.37 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.27 |
| CHEMBL300389 | — | — | 1 | 7.02 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.92 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 6.90 |
| CHEMBL1256459 | TORIN1 | — | 1 | 6.87 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 6.83 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.76 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.68 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.45 |
| CHEMBL2144069 | — | — | 1 | 6.45 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.41 |
| CHEMBL575448 | BMS-754807 | 2.0 | 1 | 6.32 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.32 |
| CHEMBL64925 | MG-132 | — | 2 | 6.31 |
| CHEMBL514499 | GW843682X | — | 1 | 6.25 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 6.20 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 2 | 6.14 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 5.87 |
| CHEMBL191384 | — | — | 1 | 5.86 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 5.85 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.78 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.76 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 5.76 |
| CHEMBL521851 | PICTILISIB | 2.0 | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.6515 | nM | 9.19 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.119 | nM | 8.67 |
| CHEMBL220241 | GSK-269962A | IC50 | = | 7.885 | nM | 8.10 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 10.77 | nM | 7.97 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 12.56 | nM | 7.90 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 42.43 | nM | 7.37 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL300389 | — | IC50 | = | 96.31 | nM | 7.02 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 120.28 | nM | 6.92 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 125.58 | nM | 6.90 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 135.87 | nM | 6.87 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 146.92 | nM | 6.83 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 173.81 | nM | 6.76 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 209.72 | nM | 6.68 |
| CHEMBL2144069 | — | IC50 | = | 351.8 | nM | 6.45 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 352.52 | nM | 6.45 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 385.99 | nM | 6.41 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 477.33 | nM | 6.32 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 482.08 | nM | 6.32 |
| CHEMBL64925 | MG-132 | IC50 | = | 490.96 | nM | 6.31 |
| CHEMBL514499 | GW843682X | IC50 | = | 564.96 | nM | 6.25 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 636.78 | nM | 6.20 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 729.79 | nM | 6.14 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 1340.1 | nM | 5.87 |
| CHEMBL191384 | — | IC50 | = | 1388.23 | nM | 5.86 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 1402.31 | nM | 5.85 |
| CHEMBL64925 | MG-132 | IC50 | = | 1499.11 | nM | 5.82 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 1643.65 | nM | 5.78 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 1735.86 | nM | 5.76 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 1751.68 | nM | 5.76 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 1886.92 | nM | 5.72 |
| CHEMBL217354 | — | IC50 | = | 2014.72 | nM | 5.70 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 2924.8 | nM | 5.53 |
| CHEMBL379300 | A-443654 | IC50 | = | 3026.19 | nM | 5.52 |
| CHEMBL1190711 | — | IC50 | = | 3300.44 | nM | 5.48 |
| CHEMBL535 | SUNITINIB | IC50 | = | 3705.08 | nM | 5.43 |
| CHEMBL1091644 | LINSITINIB | IC50 | = | 4152.13 | nM | 5.38 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4946.17 | nM | 5.31 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 5779.4 | nM | 5.24 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 5859.9 | nM | 5.23 |
| CHEMBL3349342 | — | IC50 | = | 6069.51 | nM | 5.22 |
| CHEMBL803 | CYTARABINE | IC50 | = | 6495.29 | nM | 5.19 |
| CHEMBL217092 | SARACATINIB | IC50 | = | 6732.06 | nM | 5.17 |
| CHEMBL202721 | — | IC50 | = | 6844.55 | nM | 5.17 |
| CHEMBL577784 | BX-795 | IC50 | = | 7000.06 | nM | 5.16 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 7417.91 | nM | 5.13 |
| CHEMBL483847 | — | IC50 | = | 8935.34 | nM | 5.05 |
| CHEMBL1673039 | — | IC50 | = | 8842.49 | nM | 5.05 |
| CHEMBL513909 | BI-2536 | IC50 | = | 9422.65 | nM | 5.03 |
| CHEMBL213100 | — | IC50 | = | 9965.48 | nM | 5.00 |