Assay Detail
Functional
CHEMBL2363749
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SANGER: Inhibition of human BB65-RCC cell growth in a cell viability assay.
139
Total Activities
137
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BB65-RCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 139 | 5.69 | 10.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 10.29 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 9.52 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 9.20 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.73 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.51 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.29 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 8.15 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.92 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 7.90 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.68 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 7.64 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 7.62 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 7.60 |
| CHEMBL1256459 | TORIN1 | — | 1 | 7.43 |
| CHEMBL300389 | — | — | 1 | 7.22 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 7.21 |
| CHEMBL514499 | GW843682X | — | 1 | 7.16 |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 7.08 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 7.03 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 6.99 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 6.98 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.96 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 6.92 |
| CHEMBL217354 | — | — | 1 | 6.87 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.84 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.83 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 6.76 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.57 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.51 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.05119 | nM | 10.29 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 0.3041 | nM | 9.52 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 0.6306 | nM | 9.20 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 1.853 | nM | 8.73 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 3.084 | nM | 8.51 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 5.08 | nM | 8.29 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 7.004 | nM | 8.15 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 12.04 | nM | 7.92 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 12.72 | nM | 7.90 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 20.7 | nM | 7.68 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 23.02 | nM | 7.64 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 24.16 | nM | 7.62 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 25.34 | nM | 7.60 |
| CHEMBL1256459 | TORIN1 | IC50 | = | 36.91 | nM | 7.43 |
| CHEMBL300389 | — | IC50 | = | 60.12 | nM | 7.22 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 61.84 | nM | 7.21 |
| CHEMBL514499 | GW843682X | IC50 | = | 68.86 | nM | 7.16 |
| CHEMBL5416410 | DASATINIB | IC50 | = | 82.27 | nM | 7.08 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 94.28 | nM | 7.03 |
| CHEMBL513909 | BI-2536 | IC50 | = | 102.94 | nM | 6.99 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 105.54 | nM | 6.98 |
| CHEMBL803 | CYTARABINE | IC50 | = | 110.19 | nM | 6.96 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 119.93 | nM | 6.92 |
| CHEMBL217354 | — | IC50 | = | 134.54 | nM | 6.87 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 144.71 | nM | 6.84 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 149.31 | nM | 6.83 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 175.45 | nM | 6.76 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 270.97 | nM | 6.57 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 308.05 | nM | 6.51 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 345.93 | nM | 6.46 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 444.66 | nM | 6.35 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 470.73 | nM | 6.33 |
| CHEMBL64925 | MG-132 | IC50 | = | 568.11 | nM | 6.25 |
| CHEMBL379300 | A-443654 | IC50 | = | 597.14 | nM | 6.22 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 695.45 | nM | 6.16 |
| CHEMBL585951 | — | IC50 | = | 923.66 | nM | 6.03 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 978.87 | nM | 6.01 |
| CHEMBL572878 | TOZASERTIB | IC50 | = | 1180.05 | nM | 5.93 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 1302.2 | nM | 5.88 |
| CHEMBL379975 | — | IC50 | = | 1418.85 | nM | 5.85 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 1474.36 | nM | 5.83 |
| CHEMBL189963 | PALBOCICLIB | IC50 | = | 1505.28 | nM | 5.82 |
| CHEMBL1614701 | SELUMETINIB | IC50 | = | 1838.55 | nM | 5.74 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 1898.49 | nM | 5.72 |
| CHEMBL509032 | TAE-684 | IC50 | = | 2374.93 | nM | 5.62 |
| CHEMBL105442 | CI-1040 | IC50 | = | 2406.74 | nM | 5.62 |
| CHEMBL392695 | S-TRITYL-L-CYSTEINE | IC50 | = | 2383.14 | nM | 5.62 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 2638.34 | nM | 5.58 |
| CHEMBL939 | GEFITINIB | IC50 | = | 2807.13 | nM | 5.55 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 2824.62 | nM | 5.55 |