Assay Detail
Functional
CHEMBL2363769
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SANGER: Inhibition of human C-33-A cell growth in a cell viability assay.
98
Total Activities
97
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | C-33-A |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 98 | 5.64 | 9.56 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 9.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 9.07 |
| CHEMBL3545252 | DOCETAXEL | 4.0 | 1 | 8.57 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 8.48 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 8.19 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 8.14 |
| CHEMBL1972860 | ELESCLOMOL | 3.0 | 1 | 8.12 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.01 |
| CHEMBL159 | VINBLASTINE | 4.0 | 1 | 7.90 |
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.82 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.48 |
| CHEMBL217354 | — | — | 1 | 6.96 |
| CHEMBL1879463 | DACTOLISIB | 3.0 | 1 | 6.87 |
| CHEMBL585951 | — | — | 1 | 6.60 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.49 |
| CHEMBL1201182 | TEMSIROLIMUS | 4.0 | 1 | 6.41 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 6.37 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.31 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 6.26 |
| CHEMBL1173655 | AFATINIB | 4.0 | 1 | 6.09 |
| CHEMBL2041933 | AZD-7762 | 1.0 | 1 | 6.07 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.07 |
| CHEMBL1801204 | AZD-8055 | 1.0 | 1 | 6.04 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.04 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | 5.82 |
| CHEMBL2363137 | — | — | 1 | 5.70 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 5.65 |
| CHEMBL1190711 | — | — | 1 | 5.60 |
| CHEMBL191384 | — | — | 1 | 5.57 |
| CHEMBL603469 | LESTAURTINIB | 3.0 | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL888 | GEMCITABINE | IC50 | = | 0.2733 | nM | 9.56 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 0.8482 | nM | 9.07 |
| CHEMBL3545252 | DOCETAXEL | IC50 | = | 2.659 | nM | 8.57 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 3.272 | nM | 8.48 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 6.477 | nM | 8.19 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 7.314 | nM | 8.14 |
| CHEMBL1972860 | ELESCLOMOL | IC50 | = | 7.579 | nM | 8.12 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 9.775 | nM | 8.01 |
| CHEMBL159 | VINBLASTINE | IC50 | = | 12.66 | nM | 7.90 |
| CHEMBL252164 | LUMINESPIB | IC50 | = | 15.09 | nM | 7.82 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 32.89 | nM | 7.48 |
| CHEMBL217354 | — | IC50 | = | 109.33 | nM | 6.96 |
| CHEMBL1879463 | DACTOLISIB | IC50 | = | 135.97 | nM | 6.87 |
| CHEMBL585951 | — | IC50 | = | 252.67 | nM | 6.60 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 322.05 | nM | 6.49 |
| CHEMBL1201182 | TEMSIROLIMUS | IC50 | = | 392.13 | nM | 6.41 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 431.78 | nM | 6.37 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 486.87 | nM | 6.31 |
| CHEMBL803 | CYTARABINE | IC50 | = | 550.83 | nM | 6.26 |
| CHEMBL1173655 | AFATINIB | IC50 | = | 812.97 | nM | 6.09 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 861.69 | nM | 6.07 |
| CHEMBL2041933 | AZD-7762 | IC50 | = | 861.85 | nM | 6.07 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 912.75 | nM | 6.04 |
| CHEMBL1801204 | AZD-8055 | IC50 | = | 904.42 | nM | 6.04 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | = | 1522.0 | nM | 5.82 |
| CHEMBL2363137 | — | IC50 | = | 2002.17 | nM | 5.70 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 2260.63 | nM | 5.65 |
| CHEMBL1190711 | — | IC50 | = | 2526.69 | nM | 5.60 |
| CHEMBL191384 | — | IC50 | = | 2673.93 | nM | 5.57 |
| CHEMBL603469 | LESTAURTINIB | IC50 | = | 2866.01 | nM | 5.54 |
| CHEMBL288441 | BOSUTINIB | IC50 | = | 3414.21 | nM | 5.47 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 4491.82 | nM | 5.35 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 6916.88 | nM | 5.16 |
| CHEMBL573107 | — | IC50 | = | 7478.2 | nM | 5.13 |
| CHEMBL3349342 | — | IC50 | = | 8403.88 | nM | 5.08 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 8528.86 | nM | 5.07 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 8615.29 | nM | 5.07 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 9106.88 | nM | 5.04 |
| CHEMBL521851 | PICTILISIB | IC50 | = | 9439.88 | nM | 5.03 |
| CHEMBL2137530 | SERDEMETAN | IC50 | = | 10175.3 | nM | 4.99 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 10797.47 | nM | 4.97 |
| CHEMBL34259 | METHOTREXATE | IC50 | = | 10685.38 | nM | 4.97 |
| CHEMBL258844 | — | IC50 | = | 12478.27 | nM | 4.90 |
| CHEMBL176544 | — | IC50 | = | 14852.02 | nM | 4.83 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 15317.68 | nM | 4.82 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 16621.38 | nM | 4.78 |
| CHEMBL1186585 | — | IC50 | = | 16445.91 | nM | 4.78 |
| CHEMBL2134202 | — | IC50 | = | 29219.78 | nM | 4.53 |
| CHEMBL572881 | MOTESANIB | IC50 | = | 32347.8 | nM | 4.49 |
| CHEMBL188678 | — | IC50 | = | 32772.8 | nM | 4.48 |