Assay Detail
Functional
CHEMBL2363828
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SANGER: Inhibition of human YT cell growth in a cell viability assay.
78
Total Activities
77
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | YT |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Genomics of Drug Sensitity in Cancer screening data, Wellcome Trust Sanger Institute
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 78 | 5.44 | 7.93 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | 2.0 | 1 | 7.93 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 7.88 |
| CHEMBL94657 | PATUPILONE | 3.0 | 1 | 7.73 |
| CHEMBL512504 | — | — | 1 | 7.33 |
| CHEMBL325041 | BORTEZOMIB | 3.0 | 1 | 7.21 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | 3.0 | 1 | 7.13 |
| CHEMBL2165191 | AZD-6482 | 2.0 | 1 | 6.92 |
| CHEMBL585951 | — | — | 1 | 6.69 |
| CHEMBL553025 | VINORELBINE | 4.0 | 1 | 6.66 |
| CHEMBL608533 | MIDOSTAURIN | 4.0 | 1 | 6.58 |
| CHEMBL1171837 | PONATINIB | 4.0 | 1 | 6.57 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.42 |
| CHEMBL105 | MITOMYCIN | 4.0 | 1 | 6.33 |
| CHEMBL449158 | BRYOSTATIN 1 | 2.0 | 1 | 6.30 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.98 |
| CHEMBL888 | GEMCITABINE | 4.0 | 1 | 5.89 |
| CHEMBL6067492 | BLEOMYCIN | 4.0 | 1 | 5.88 |
| CHEMBL472940 | — | — | 1 | 5.86 |
| CHEMBL289228 | TIPIFARNIB | 3.0 | 1 | 5.78 |
| CHEMBL2363137 | — | — | 1 | 5.74 |
| CHEMBL1190711 | — | — | 1 | 5.63 |
| CHEMBL1673039 | — | — | 1 | 5.46 |
| CHEMBL135561 | — | — | 1 | 5.44 |
| CHEMBL64925 | MG-132 | — | 2 | 5.36 |
| CHEMBL591429 | PAC-1 | 1.0 | 1 | 5.20 |
| CHEMBL483847 | — | — | 1 | 5.19 |
| CHEMBL258844 | — | — | 1 | 5.12 |
| CHEMBL2144069 | — | — | 1 | 5.09 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 5.06 |
| CHEMBL1242367 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL252164 | LUMINESPIB | IC50 | = | 11.79 | nM | 7.93 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 13.1 | nM | 7.88 |
| CHEMBL94657 | PATUPILONE | IC50 | = | 18.74 | nM | 7.73 |
| CHEMBL512504 | — | IC50 | = | 46.7 | nM | 7.33 |
| CHEMBL325041 | BORTEZOMIB | IC50 | = | 61.8 | nM | 7.21 |
| CHEMBL2107358 | OBATOCLAX MESYLATE | IC50 | = | 73.45 | nM | 7.13 |
| CHEMBL2165191 | AZD-6482 | IC50 | = | 120.66 | nM | 6.92 |
| CHEMBL585951 | — | IC50 | = | 204.44 | nM | 6.69 |
| CHEMBL553025 | VINORELBINE | IC50 | = | 218.54 | nM | 6.66 |
| CHEMBL608533 | MIDOSTAURIN | IC50 | = | 262.82 | nM | 6.58 |
| CHEMBL1171837 | PONATINIB | IC50 | = | 269.74 | nM | 6.57 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 383.89 | nM | 6.42 |
| CHEMBL105 | MITOMYCIN | IC50 | = | 463.33 | nM | 6.33 |
| CHEMBL449158 | BRYOSTATIN 1 | IC50 | = | 495.13 | nM | 6.30 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1045.68 | nM | 5.98 |
| CHEMBL888 | GEMCITABINE | IC50 | = | 1285.59 | nM | 5.89 |
| CHEMBL6067492 | BLEOMYCIN | IC50 | = | 1315.67 | nM | 5.88 |
| CHEMBL472940 | — | IC50 | = | 1390.36 | nM | 5.86 |
| CHEMBL289228 | TIPIFARNIB | IC50 | = | 1648.49 | nM | 5.78 |
| CHEMBL2363137 | — | IC50 | = | 1826.5 | nM | 5.74 |
| CHEMBL1190711 | — | IC50 | = | 2339.36 | nM | 5.63 |
| CHEMBL1673039 | — | IC50 | = | 3479.28 | nM | 5.46 |
| CHEMBL135561 | — | IC50 | = | 3660.37 | nM | 5.44 |
| CHEMBL64925 | MG-132 | IC50 | = | 4354.24 | nM | 5.36 |
| CHEMBL591429 | PAC-1 | IC50 | = | 6303.73 | nM | 5.20 |
| CHEMBL483847 | — | IC50 | = | 6461.43 | nM | 5.19 |
| CHEMBL258844 | — | IC50 | = | 7504.16 | nM | 5.12 |
| CHEMBL2144069 | — | IC50 | = | 8116.95 | nM | 5.09 |
| CHEMBL413 | SIROLIMUS | IC50 | = | 8624.27 | nM | 5.06 |
| CHEMBL64925 | MG-132 | IC50 | = | 9836.73 | nM | 5.01 |
| CHEMBL1242367 | — | IC50 | = | 9703.0 | nM | 5.01 |
| CHEMBL558642 | GSK-650394 | IC50 | = | 9899.69 | nM | 5.00 |
| CHEMBL1084546 | PF-00562271 | IC50 | = | 10400.13 | nM | 4.98 |
| CHEMBL221137 | EMBELIN | IC50 | = | 12815.64 | nM | 4.89 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 18271.2 | nM | 4.74 |
| CHEMBL209148 | — | IC50 | = | 19433.98 | nM | 4.71 |
| CHEMBL575448 | BMS-754807 | IC50 | = | 20686.99 | nM | 4.68 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 21469.06 | nM | 4.67 |
| CHEMBL92309 | — | IC50 | = | 23398.36 | nM | 4.63 |
| CHEMBL259181 | — | IC50 | = | 31114.91 | nM | 4.51 |
| CHEMBL300389 | — | IC50 | = | 34535.47 | nM | 4.46 |
| CHEMBL1023 | BEXAROTENE | IC50 | = | 37300.06 | nM | 4.43 |
| CHEMBL941 | IMATINIB | IC50 | = | 38520.94 | nM | 4.41 |
| CHEMBL477772 | PAZOPANIB | IC50 | = | 46506.68 | nM | 4.33 |
| CHEMBL450786 | PHA-665752 | IC50 | = | 53995.79 | nM | 4.27 |
| CHEMBL514499 | GW843682X | IC50 | = | 59052.92 | nM | 4.23 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 59082.63 | nM | 4.23 |
| CHEMBL1336 | SORAFENIB | IC50 | = | 59310.78 | nM | 4.23 |
| CHEMBL513909 | BI-2536 | IC50 | = | 62064.55 | nM | 4.21 |
| CHEMBL27759 | ENTINOSTAT | IC50 | = | 61888.41 | nM | 4.21 |