Assay Detail
Functional
CHEMBL2379301
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Cytotoxicity against human Jurkat cells after 48 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Cytotoxic 3,4,5-trimethoxychalcones as mitotic arresters and cell migration inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.81 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | 4.0 | 1 | 8.11 |
| CHEMBL220818 | — | — | 1 | 6.30 |
| CHEMBL285901 | — | — | 1 | 5.92 |
| CHEMBL484145 | — | — | 1 | 5.23 |
| CHEMBL7976 | CHALCONE | — | 1 | 4.77 |
| CHEMBL1946988 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL107 | COLCHICINE | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL220818 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL285901 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL484145 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL7976 | CHALCONE | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL1946988 | — | IC50 | = | 30000.0 | nM | 4.52 |