Assay Detail
Binding
CHEMBL2379310
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Inhibition of acetylcholine esterase (unknown origin) using acetylthiocholine as substrate incubated for 15 mins prior to substrate addition measured after 5 mins by spectrophotometry
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Triazolothiadiazoles and triazolothiadiazines--biologically attractive scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.84 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.68 |
| CHEMBL2375483 | — | — | 1 | 6.46 |
| CHEMBL2377874 | — | — | 1 | 5.75 |
| CHEMBL2377878 | — | — | 1 | 5.75 |
| CHEMBL2377877 | — | — | 1 | 5.75 |
| CHEMBL2377876 | — | — | 1 | 5.75 |
| CHEMBL2377875 | — | — | 1 | 5.75 |
| CHEMBL2375480 | — | — | 1 | 5.75 |
| CHEMBL2377873 | — | — | 1 | 5.75 |
| CHEMBL2375482 | — | — | 1 | 5.75 |
| CHEMBL2375481 | — | — | 1 | 5.75 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | 4.0 | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL502 | DONEPEZIL | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL2375483 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL2377874 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2377878 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2377877 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2377876 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2377875 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2375480 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2377873 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2375482 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL2375481 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL211471 | NEOSTIGMINE METHYLSULFATE | IC50 | = | 69100.0 | nM | 4.16 |