Compound Detail
CHEMBL2375482
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Basic Information
| ChEMBL ID | CHEMBL2375482 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QYCOFCLOPMEREV-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
347.2
MW (Da)
3.88
ALogP
6
HBA
0
HBD
56.2
PSA (Ų)
0.55
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Intestinal-type alkaline phosphatase CHEMBL5695 | IC50 | 7.21 | 7.21 | 61.0 | 1 |
| Acetylcholinesterase CHEMBL220 | IC50 | 5.75 | 5.75 | 1780.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Intestinal-type alkaline phosphatase | IC50 | = | 61.0 | nM | 7.21 | Inhibition of calf intestinal alkaline phosphatase using p-NPP as substrate incu... | 23603045 |
| Acetylcholinesterase | IC50 | = | 1780.0 | nM | 5.75 | Inhibition of acetylcholine esterase (unknown origin) using acetylthiocholine as... | 23603045 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23603045 | 10.1016/j.ejmech.2013.01.060 | Acetylcholinesterase | 1 |
| 23603045 | 10.1016/j.ejmech.2013.01.060 | Intestinal-type alkaline phosphatase | 1 |
Data from ChEMBL 36 via Core Engine