Assay Detail
Binding
CHEMBL2380038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H] N-methylscopolamine from muscarinic acetylcholine receptor in guinea pig brain homogenate after 30 mins by scintillation counting analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Brain |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.72 | 9.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2106570 | METHYLBENACTYZIUM BROMIDE | 2.0 | 1 | 9.89 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.60 |
| CHEMBL2377387 | — | — | 1 | 8.28 |
| CHEMBL2377269 | — | — | 1 | 8.24 |
| CHEMBL2377267 | — | — | 1 | 8.10 |
| CHEMBL1101 | BIPERIDEN | 4.0 | 1 | 7.98 |
| CHEMBL2377392 | — | — | 1 | 7.67 |
| CHEMBL2377261 | — | — | 1 | 7.48 |
| CHEMBL2377388 | — | — | 1 | 6.38 |
| CHEMBL2377386 | — | — | 1 | 6.11 |
| CHEMBL2377390 | — | — | 1 | 6.08 |
| CHEMBL2377389 | — | — | 1 | 5.92 |
| CHEMBL2110777 | CLOFENETAMINE | 2.0 | 1 | 5.91 |
| CHEMBL2377382 | — | — | 1 | 5.87 |
| CHEMBL2377391 | — | — | 1 | 5.39 |
| CHEMBL2377264 | — | — | 1 | 5.38 |
| CHEMBL2377263 | — | — | 1 | 5.24 |
| CHEMBL2377266 | — | — | 1 | 4.72 |
| CHEMBL2377265 | — | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2106570 | METHYLBENACTYZIUM BROMIDE | Ki | = | 0.129 | nM | 9.89 |
| CHEMBL517712 | ATROPINE | Ki | = | 2.49 | nM | 8.60 |
| CHEMBL2377387 | — | Ki | = | 5.27 | nM | 8.28 |
| CHEMBL2377269 | — | Ki | = | 5.79 | nM | 8.24 |
| CHEMBL2377267 | — | Ki | = | 7.92 | nM | 8.10 |
| CHEMBL1101 | BIPERIDEN | Ki | = | 10.5 | nM | 7.98 |
| CHEMBL2377392 | — | Ki | = | 21.3 | nM | 7.67 |
| CHEMBL2377261 | — | Ki | = | 33.3 | nM | 7.48 |
| CHEMBL2377388 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL2377386 | — | Ki | = | 775.0 | nM | 6.11 |
| CHEMBL2377390 | — | Ki | = | 833.0 | nM | 6.08 |
| CHEMBL2377389 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL2110777 | CLOFENETAMINE | Ki | = | 1220.0 | nM | 5.91 |
| CHEMBL2377382 | — | Ki | = | 1350.0 | nM | 5.87 |
| CHEMBL2377391 | — | Ki | = | 4100.0 | nM | 5.39 |
| CHEMBL2377264 | — | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL2377263 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL2377266 | — | Ki | = | 18900.0 | nM | 4.72 |
| CHEMBL2377265 | — | Ki | = | 33100.0 | nM | 4.48 |