Compound Detail
CHEMBL2377266
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Basic Information
| ChEMBL ID | CHEMBL2377266 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VJKXDMWRHJRMLE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
382.3
MW (Da)
3.54
ALogP
6
HBA
1
HBD
56.1
PSA (Ų)
0.86
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 CHEMBL216 | Ki | 9.23 | 9.23 | 0.6 | 1 |
| Unchecked CHEMBL612545 | Ki | 4.72 | 4.72 | 18900.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M1 | Ki | = | 0.594 | nM | 9.23 | Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor expre... | 23523385 |
| Unchecked | Ki | = | 18900.0 | nM | 4.72 | Displacement of [3H] N-methylscopolamine from muscarinic acetylcholine receptor ... | 23523385 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 23523385 | 10.1016/j.bmc.2013.01.072 | Muscarinic acetylcholine receptor M1 | 1 |
| 23523385 | 10.1016/j.bmc.2013.01.072 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine