Assay Detail
Binding
CHEMBL2380035
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H] N-methylscopolamine from human muscarinic M1 receptor expressed in CHOK1 cells after 30 mins by scintillation counting analysis
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO-K1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of subtype selective muscarinic receptor antagonists as alternatives to atropine using in silico pharmacophore modeling and virtual screening methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 7.81 | 9.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2377266 | — | — | 1 | 9.23 |
| CHEMBL37372 | — | — | 1 | 9.05 |
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.04 |
| CHEMBL2377387 | — | — | 1 | 8.89 |
| CHEMBL2377267 | — | — | 1 | 8.88 |
| CHEMBL2106570 | METHYLBENACTYZIUM BROMIDE | 2.0 | 1 | 8.80 |
| CHEMBL1101 | BIPERIDEN | 4.0 | 1 | 8.63 |
| CHEMBL2377385 | — | — | 1 | 8.24 |
| CHEMBL2377383 | — | — | 1 | 8.24 |
| CHEMBL2377269 | — | — | 1 | 8.11 |
| CHEMBL2377392 | — | — | 1 | 7.97 |
| CHEMBL26505 | APROFENE | 2.0 | 1 | 7.82 |
| CHEMBL2377384 | — | — | 1 | 7.07 |
| CHEMBL1191560 | — | — | 1 | 6.78 |
| CHEMBL2377388 | — | — | 1 | 6.75 |
| CHEMBL2110892 | BIETAMIVERINE | 2.0 | 1 | 6.57 |
| CHEMBL2377262 | — | — | 1 | 6.29 |
| CHEMBL2377261 | — | — | 1 | 6.01 |
| CHEMBL2377264 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2377266 | — | Ki | = | 0.594 | nM | 9.23 |
| CHEMBL37372 | — | Ki | = | 0.881 | nM | 9.05 |
| CHEMBL517712 | ATROPINE | Ki | = | 0.922 | nM | 9.04 |
| CHEMBL2377387 | — | Ki | = | 1.29 | nM | 8.89 |
| CHEMBL2377267 | — | Ki | = | 1.32 | nM | 8.88 |
| CHEMBL2106570 | METHYLBENACTYZIUM BROMIDE | Ki | = | 1.59 | nM | 8.80 |
| CHEMBL1101 | BIPERIDEN | Ki | = | 2.36 | nM | 8.63 |
| CHEMBL2377385 | — | Ki | = | 5.78 | nM | 8.24 |
| CHEMBL2377383 | — | Ki | = | 5.75 | nM | 8.24 |
| CHEMBL2377269 | — | Ki | = | 7.75 | nM | 8.11 |
| CHEMBL2377392 | — | Ki | = | 10.7 | nM | 7.97 |
| CHEMBL26505 | APROFENE | Ki | = | 15.1 | nM | 7.82 |
| CHEMBL2377384 | — | Ki | = | 85.7 | nM | 7.07 |
| CHEMBL1191560 | — | Ki | = | 166.0 | nM | 6.78 |
| CHEMBL2377388 | — | Ki | = | 176.0 | nM | 6.75 |
| CHEMBL2110892 | BIETAMIVERINE | Ki | = | 271.0 | nM | 6.57 |
| CHEMBL2377262 | — | Ki | = | 519.0 | nM | 6.29 |
| CHEMBL2377261 | — | Ki | = | 971.0 | nM | 6.01 |
| CHEMBL2377264 | — | Ki | = | 1040.0 | nM | 5.98 |