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Compound Detail

CHEMBL2377267

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CCN(CC)CCOC(=O)C(O)(c1cccs1)C1CCCCC1

Basic Information

ChEMBL ID CHEMBL2377267
Phase Preclinical
Structure Type MOL
InChI Key IEENUMOCDKBVGC-UHFFFAOYSA-N
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

339.5
MW (Da)
3.40
ALogP
5
HBA
1
HBD
49.8
PSA (Ų)
0.74
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H29NO3S
MW 339.50
Aromatic Rings 1
Heavy Atoms 23
NP-Likeness -0.77

Activity Summary

Ki 5 meas. best 8.88

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 8.88 8.88 1.3 1
Muscarinic acetylcholine receptor M4
CHEMBL1821
Ki 8.83 8.83 1.5 1
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 8.18 8.18 6.5 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 8.1 8.1 7.9 1
Unchecked
CHEMBL612545
Ki 8.1 8.1 7.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23523385 10.1016/j.bmc.2013.01.072 Muscarinic acetylcholine receptor M1 and M3 2
23523385 10.1016/j.bmc.2013.01.072 Muscarinic acetylcholine receptor M4 1
23523385 10.1016/j.bmc.2013.01.072 Muscarinic acetylcholine receptor M3 1
23523385 10.1016/j.bmc.2013.01.072 Muscarinic acetylcholine receptor M2 1
23523385 10.1016/j.bmc.2013.01.072 Muscarinic acetylcholine receptor M1 1
23523385 10.1016/j.bmc.2013.01.072 Unchecked 1

Data from ChEMBL 36 via Core Engine