Assay Detail
Binding
CHEMBL2382523
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Agonist activity at human mGlu8 receptor expressed in golden Syrian hamster AV12 cells coexpressing EAAT1 after 20 mins by FLIPR assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | AV12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.19 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2381641 | — | — | 1 | 5.80 |
| CHEMBL2381649 | — | — | 1 | 5.37 |
| CHEMBL2381640 | — | — | 1 | 5.18 |
| CHEMBL2381652 | — | — | 1 | 4.94 |
| CHEMBL2381645 | — | — | 1 | 4.92 |
| CHEMBL2381644 | — | — | 1 | 4.91 |
| CHEMBL2381651 | — | — | 1 | - |
| CHEMBL2381650 | — | — | 1 | - |
| CHEMBL2381648 | — | — | 1 | - |
| CHEMBL2381647 | — | — | 1 | - |
| CHEMBL2381646 | — | — | 1 | - |
| CHEMBL2381643 | — | — | 1 | - |
| CHEMBL2381642 | — | — | 1 | - |
| CHEMBL192051 | — | — | 1 | - |
| CHEMBL365368 | — | — | 1 | - |
| CHEMBL8759 | EGLUMETAD | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2381641 | — | EC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL2381649 | — | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL2381640 | — | EC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL2381652 | — | EC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL2381645 | — | EC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2381644 | — | EC50 | = | 12400.0 | nM | 4.91 |
| CHEMBL2381651 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2381650 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2381648 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2381647 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2381646 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2381643 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL2381642 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL192051 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL365368 | — | EC50 | > | 25000.0 | nM | - |
| CHEMBL8759 | EGLUMETAD | EC50 | > | 25000.0 | nM | - |