Assay Detail
Binding
CHEMBL2384301
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Inhibition of equine serum BuChE using S-butyrylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition measured after 30 mins by Ellman's method
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Equus caballus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A facile chemo-, regio- and stereoselective synthesis and cholinesterase inhibitory activity of spirooxindole-pyrrolizine-piperidine hybrids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 4.70 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2380672 | — | — | 1 | 5.50 |
| CHEMBL2380677 | — | — | 1 | 5.44 |
| CHEMBL2380670 | — | — | 1 | 5.11 |
| CHEMBL2380667 | — | — | 1 | 5.01 |
| CHEMBL2380669 | — | — | 1 | 4.82 |
| CHEMBL2380668 | — | — | 1 | 4.81 |
| CHEMBL2380671 | — | — | 1 | 4.76 |
| CHEMBL2380673 | — | — | 1 | 4.76 |
| CHEMBL659 | GALANTAMINE | 4.0 | 1 | 4.71 |
| CHEMBL2380674 | — | — | 1 | 4.70 |
| CHEMBL156016 | — | — | 1 | 4.66 |
| CHEMBL2380675 | — | — | 1 | 4.65 |
| CHEMBL2332547 | — | — | 1 | 4.64 |
| CHEMBL2380676 | — | — | 1 | 4.55 |
| CHEMBL2332539 | — | — | 1 | 4.54 |
| CHEMBL2332546 | — | — | 1 | 4.53 |
| CHEMBL2332538 | — | — | 1 | 4.52 |
| CHEMBL350032 | — | — | 1 | 4.51 |
| CHEMBL454594 | — | — | 1 | 4.46 |
| CHEMBL2332535 | — | — | 1 | 4.44 |
| CHEMBL152675 | — | — | 1 | 4.42 |
| CHEMBL2332537 | — | — | 1 | 4.29 |
| CHEMBL2332536 | — | — | 1 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2380672 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL2380677 | — | IC50 | = | 3640.0 | nM | 5.44 |
| CHEMBL2380670 | — | IC50 | = | 7820.0 | nM | 5.11 |
| CHEMBL2380667 | — | IC50 | = | 9650.0 | nM | 5.01 |
| CHEMBL2380669 | — | IC50 | = | 15110.0 | nM | 4.82 |
| CHEMBL2380668 | — | IC50 | = | 15440.0 | nM | 4.81 |
| CHEMBL2380671 | — | IC50 | = | 17420.0 | nM | 4.76 |
| CHEMBL2380673 | — | IC50 | = | 17210.0 | nM | 4.76 |
| CHEMBL659 | GALANTAMINE | IC50 | = | 19340.0 | nM | 4.71 |
| CHEMBL2380674 | — | IC50 | = | 20140.0 | nM | 4.70 |
| CHEMBL156016 | — | IC50 | = | 22060.0 | nM | 4.66 |
| CHEMBL2380675 | — | IC50 | = | 22170.0 | nM | 4.65 |
| CHEMBL2332547 | — | IC50 | = | 23120.0 | nM | 4.64 |
| CHEMBL2380676 | — | IC50 | = | 28160.0 | nM | 4.55 |
| CHEMBL2332539 | — | IC50 | = | 28920.0 | nM | 4.54 |
| CHEMBL2332546 | — | IC50 | = | 29370.0 | nM | 4.53 |
| CHEMBL2332538 | — | IC50 | = | 30020.0 | nM | 4.52 |
| CHEMBL350032 | — | IC50 | = | 30580.0 | nM | 4.51 |
| CHEMBL454594 | — | IC50 | = | 35070.0 | nM | 4.46 |
| CHEMBL2332535 | — | IC50 | = | 36620.0 | nM | 4.44 |
| CHEMBL152675 | — | IC50 | = | 38190.0 | nM | 4.42 |
| CHEMBL2332537 | — | IC50 | = | 51160.0 | nM | 4.29 |
| CHEMBL2332536 | — | IC50 | = | 54040.0 | nM | 4.27 |