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Assay Detail

CHEMBL2384628

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human T47D cells by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T47D
Confidence 1 — Organism
Curated By Autocuration

Target

T47D (CHEMBL614361)
Type CELL-LINE
Organism Homo sapiens

Publication

Chalcones, inhibitors for topoisomerase I and cathepsin B and L, as potential anti-cancer agents.
Kim SH, Lee E, Baek KH, Kwon HB, Woo H, Lee ES, Kwon Y, Na Y.
Bioorg Med Chem Lett (2013) 23 : 3320 -3324
PubMed 23608763 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.25 7.16

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL65 CAMPTOTHECIN -1.0 1 7.16
CHEMBL2382055 1 5.98
CHEMBL2382116 1 5.86
CHEMBL53463 DOXORUBICIN 4.0 1 5.54
CHEMBL44657 ETOPOSIDE 4.0 1 5.30
CHEMBL2382117 1 5.16
CHEMBL1928752 1 5.08
CHEMBL2382112 1 5.07
CHEMBL2382059 1 4.96
CHEMBL141530 ECHINATIN 1 4.92
CHEMBL2382113 1 4.91
CHEMBL8102 1 4.86
CHEMBL2382119 1 4.67
CHEMBL2382058 1 4.66
CHEMBL2148111 1 4.66
CHEMBL2382114 1 -
CHEMBL2382057 1 -
CHEMBL2382056 1 -
CHEMBL2382054 1 -
CHEMBL2382115 1 -
CHEMBL2382118 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL65 CAMPTOTHECIN IC50 = 70.0 nM 7.16
CHEMBL2382055 IC50 = 1050.0 nM 5.98
CHEMBL2382116 IC50 = 1370.0 nM 5.86
CHEMBL53463 DOXORUBICIN IC50 = 2910.0 nM 5.54
CHEMBL44657 ETOPOSIDE IC50 = 4980.0 nM 5.30
CHEMBL2382117 IC50 = 6990.0 nM 5.16
CHEMBL1928752 IC50 = 8310.0 nM 5.08
CHEMBL2382112 IC50 = 8510.0 nM 5.07
CHEMBL2382059 IC50 = 10900.0 nM 4.96
CHEMBL141530 ECHINATIN IC50 = 12110.0 nM 4.92
CHEMBL2382113 IC50 = 12330.0 nM 4.91
CHEMBL8102 IC50 = 13830.0 nM 4.86
CHEMBL2382119 IC50 = 21300.0 nM 4.67
CHEMBL2382058 IC50 = 21880.0 nM 4.66
CHEMBL2148111 IC50 = 21880.0 nM 4.66
CHEMBL2382114 IC50 - -
CHEMBL2382057 IC50 > 25000.0 nM -
CHEMBL2382056 IC50 - -
CHEMBL2382054 IC50 - -
CHEMBL2382115 IC50 > 25000.0 nM -
CHEMBL2382118 IC50 > 25000.0 nM -