Assay Detail
Functional
CHEMBL2388516
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Cytotoxicity against human U373 cells after 3 days by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | U-373MG ATCC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship analysis of bufadienolide-induced in vitro growth inhibitory effects on mouse and human cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.73 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2385658 | — | — | 1 | 8.52 |
| CHEMBL1095238 | HELLEBRIN | — | 1 | 7.44 |
| CHEMBL2385661 | — | — | 1 | 7.21 |
| CHEMBL463064 | BUFOTALIN | — | 1 | 7.13 |
| CHEMBL222863 | OUABAIN | -1.0 | 1 | 7.11 |
| CHEMBL2385660 | ARGENTINOGENIN | — | 1 | 7.07 |
| CHEMBL1751 | DIGOXIN | 4.0 | 1 | 6.84 |
| CHEMBL2385659 | — | — | 1 | 6.44 |
| CHEMBL2385663 | — | — | 1 | 6.42 |
| CHEMBL2385662 | SCILLARENONE | — | 1 | 6.40 |
| CHEMBL2385666 | — | — | 1 | 5.15 |
| CHEMBL2385664 | — | — | 1 | 5.05 |
| CHEMBL2385665 | BUFARENOGIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2385658 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1095238 | HELLEBRIN | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2385661 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL463064 | BUFOTALIN | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL222863 | OUABAIN | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL2385660 | ARGENTINOGENIN | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL1751 | DIGOXIN | IC50 | = | 146.0 | nM | 6.84 |
| CHEMBL2385659 | — | IC50 | = | 362.0 | nM | 6.44 |
| CHEMBL2385663 | — | IC50 | = | 384.0 | nM | 6.42 |
| CHEMBL2385662 | SCILLARENONE | IC50 | = | 399.0 | nM | 6.40 |
| CHEMBL2385666 | — | IC50 | = | 7046.0 | nM | 5.15 |
| CHEMBL2385664 | — | IC50 | = | 8809.0 | nM | 5.05 |
| CHEMBL2385665 | BUFARENOGIN | IC50 | > | 10000.0 | nM | - |