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Compound Detail

CHEMBL2385661

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C[C@]12CC[C@H]3[C@@H](CC[C@H]4C[C@@H](O)CC[C@@]43C=O)[C@@]1(O)CC[C@@H]2c1ccc(=O)oc1

Basic Information

ChEMBL ID CHEMBL2385661
Phase Preclinical
Structure Type MOL
InChI Key STSJQAAJJHGCMJ-XZOYFZSUSA-N
5
Targets
6
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names

Molecular Properties

400.5
MW (Da)
3.42
ALogP
5
HBA
2
HBD
87.7
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C24H32O5
MW 400.52
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness 3.08

Activity Summary

IC50 6 meas. best 7.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 7.4 7.305 40.0 2
A549
CHEMBL392
IC50 7.29 7.29 51.0 1
MCF7
CHEMBL387
IC50 6.56 6.56 278.0 1
SK-MEL-28
CHEMBL614919
IC50 6.47 6.47 336.0 1
PC-3
CHEMBL390
IC50 5.61 5.61 2431.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine