Assay Detail
Binding
CHEMBL2389045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Gloeobacter violaceus ligand-gated ion channel expressed in Xenopus oocytes assessed as inhibition of MES buffer pH 5.5 -induced currents after 30 secs by voltage clamp technique
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gloeobacter violaceus |
| Cell Type | Oocyte |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 4.49 | 5.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66879 | COUMARIC ACID | — | 1 | 5.02 |
| CHEMBL233295 | ISOFERULIC ACID | — | 1 | 4.87 |
| CHEMBL1771752 | 3-CHLORO-CINNAMIC ACID | — | 1 | 4.86 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | 4.78 |
| CHEMBL2387748 | — | — | 1 | 4.60 |
| CHEMBL1173153 | — | — | 1 | 4.54 |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | 4.46 |
| CHEMBL173521 | — | — | 1 | 4.27 |
| CHEMBL114648 | BETA-NAPHTOIC ACID | — | 1 | 4.21 |
| CHEMBL1321891 | — | — | 1 | 4.13 |
| CHEMBL2387750 | — | — | 1 | 4.08 |
| CHEMBL136927 | DIHYDROCAFFEIC ACID | — | 1 | 4.06 |
| CHEMBL17001 | METHYLCAFFEATE | — | 1 | - |
| CHEMBL17347 | ETHYL CAFFEATE | — | 1 | - |
| CHEMBL305202 | — | — | 1 | - |
| CHEMBL2387747 | CINNAMONITRILE | — | 1 | - |
| CHEMBL1778420 | — | — | 1 | - |
| CHEMBL2148183 | — | — | 1 | - |
| CHEMBL2387749 | (E)-N-METHOXYCINNAMAMIDE | — | 1 | - |
| CHEMBL320295 | O,O'-DIMETHYLCAFFEIC ACID | — | 1 | - |
| CHEMBL1234624 | — | — | 1 | - |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | — | 1 | - |
| CHEMBL1160352 | — | — | 1 | - |
| CHEMBL1830821 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66879 | COUMARIC ACID | IC50 | = | 9590.0 | nM | 5.02 |
| CHEMBL233295 | ISOFERULIC ACID | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL1771752 | 3-CHLORO-CINNAMIC ACID | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL2387748 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL1173153 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL27246 | CINNAMIC ACID | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL173521 | — | IC50 | = | 53300.0 | nM | 4.27 |
| CHEMBL114648 | BETA-NAPHTOIC ACID | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL1321891 | — | IC50 | = | 73900.0 | nM | 4.13 |
| CHEMBL2387750 | — | IC50 | = | 83500.0 | nM | 4.08 |
| CHEMBL136927 | DIHYDROCAFFEIC ACID | IC50 | = | 86800.0 | nM | 4.06 |
| CHEMBL17001 | METHYLCAFFEATE | IC50 | = | 388000.0 | nM | - |
| CHEMBL17347 | ETHYL CAFFEATE | IC50 | = | 246000.0 | nM | - |
| CHEMBL305202 | — | IC50 | = | 295000.0 | nM | - |
| CHEMBL2387747 | CINNAMONITRILE | IC50 | - | — | - | |
| CHEMBL1778420 | — | IC50 | - | — | - | |
| CHEMBL2148183 | — | IC50 | = | 7940000.0 | nM | - |
| CHEMBL2387749 | (E)-N-METHOXYCINNAMAMIDE | IC50 | - | — | - | |
| CHEMBL320295 | O,O'-DIMETHYLCAFFEIC ACID | IC50 | = | 206000.0 | nM | - |
| CHEMBL1234624 | — | IC50 | - | — | - | |
| CHEMBL83294 | COUMARIN-3-CARBOXYLIC ACID | IC50 | = | 282000.0 | nM | - |
| CHEMBL1160352 | — | IC50 | = | 347000.0 | nM | - |
| CHEMBL1830821 | — | IC50 | = | 168000.0 | nM | - |